Navigating oligodendrocyte precursor cell aging in brain health

IF 5.3 3区医学 Q2 CELL BIOLOGY Mechanisms of Ageing and Development Pub Date : 2024-06-29 DOI:10.1016/j.mad.2024.111959

Freddy Leenders , Lisa Koole , Helena Slaets , Assia Tiane , Daniel van den Hove , Tim Vanmierlo

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Abstract

Oligodendrocyte precursor cells (OPCs) comprise 5–8 % of the adult glial cell population and stand out as the most proliferative cell type in the central nervous system (CNS). OPCs are responsible for generating oligodendrocytes (OLs), the myelinating cells of the CNS. However, OPC functions decline as we age, resulting in impaired differentiation and inadequate remyelination. This review explores the cellular and molecular changes associated with OPC aging, and their impact on OPC differentiation and functionality. Furthermore, it examines the impact of OPC aging within the context of multiple sclerosis and Alzheimer’s disease, both neurodegenerative conditions wherein aged OPCs exacerbate disease progression by impeding remyelination. Moreover, various pharmacological interventions targeting pathways related to senescence and differentiation are discussed as potential strategies to rejuvenate aged OPCs. Enhancing our understanding of OPC aging mechanisms holds promise for developing new therapies to improve remyelination and repair in age-related neurodegenerative disorders.

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导航大脑健康中的少突胶质前体细胞老化。

少突胶质细胞前体细胞（OPC）占成人胶质细胞总数的 5-8%，是中枢神经系统（CNS）中增殖能力最强的细胞类型。OPC 负责生成中枢神经系统的髓鞘细胞--少突胶质细胞（OL）。然而，随着年龄的增长，OPC的功能会下降，导致分化受损和再髓鞘化不足。本综述探讨了与OPC衰老相关的细胞和分子变化，以及这些变化对OPC分化和功能的影响。此外，它还研究了多发性硬化症和阿尔茨海默病中 OPC 衰老的影响，这两种神经退行性疾病中，衰老的 OPC 会阻碍髓鞘再形成，从而加剧疾病的进展。此外，还讨论了针对衰老和分化相关通路的各种药物干预措施，以此作为使老化 OPCs 恢复活力的潜在策略。加强我们对OPC衰老机制的了解有望开发出新的疗法，改善与年龄相关的神经退行性疾病的再髓鞘化和修复。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mechanisms of Ageing and Development 医学-老年医学

CiteScore

11.10

自引率

1.90%

发文量

审稿时长

32 days

期刊介绍： Mechanisms of Ageing and Development is a multidisciplinary journal aimed at revealing the molecular, biochemical and biological mechanisms that underlie the processes of aging and development in various species as well as of age-associated diseases. Emphasis is placed on investigations that delineate the contribution of macromolecular damage and cytotoxicity, genetic programs, epigenetics and genetic instability, mitochondrial function, alterations of metabolism and innovative anti-aging approaches. For all of the mentioned studies it is necessary to address the underlying mechanisms. Mechanisms of Ageing and Development publishes original research, review and mini-review articles. The journal also publishes Special Issues that focus on emerging research areas. Special issues may include all types of articles following peered review. Proposals should be sent directly to the Editor-in-Chief.

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