Study on the Relationship Between MRI Functional Imaging and Multiple Immunohistochemical Features of Glioma: A Noninvasive and More Precise Glioma Management.

IF 2.2 4区医学 Q3 BIOCHEMICAL RESEARCH METHODS Molecular Imaging Pub Date : 2024-06-11 eCollection Date: 2024-01-01 DOI:10.1177/15353508241261583

Jing Li, Jingtao Sun, Ning Wang, Yan Zhang

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Abstract

Objective: To investigate the performance of diffusion-tensor imaging (DTI) and hydrogen proton magnetic resonance spectroscopy (¹H-MRS) parameters in predicting the immunohistochemistry (IHC) biomarkers of glioma.

Methods: Patients with glioma confirmed by pathology from March 2015 to September 2019 were analyzed, the preoperative DTI and ¹H-MRS images were collected, apparent diffusion coefficient (ADC) and fractional anisotropy (FA), in the lesion area were measured, the relative values relative ADC (rADC) and relative FA (rFA) were obtained by the ratio of them in the lesion area to the contralateral normal area. The peak of each metabolite in the lesion area of ¹H-MRS image: N-acetylaspartate (NAA), choline (Cho), and creatine (Cr), and metabolite ratio: NAA/Cho, NAA/(Cho + Cr) were selected and calculated. The preoperative IHC data were collected including CD34, Ki-67, p53, S-100, syn, vimentin, NeuN, Nestin, and glial fibrillary acidic protein.

Results: One predicting parameter of DTI was screened, the rADC of the Ki-67 positive group was lower than that of the negative group. Two parameters of ¹H-MRS were found to have significant reference values for glioma grades, the NAA and Cr decreased as the grade of glioma increased, moreover, Ki-67 Li was negatively correlated with NAA and Cr.

Conclusion: NAA and Cr have potential application value in predicting glioma grades and tumor proliferation activity. Only rADC has predictive value for Ki-67 expression among DTI parameters.

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胶质瘤核磁共振功能成像与多种免疫组化特征的关系研究：无创、更精确的胶质瘤管理。

目的研究弥散张量成像（DTI）和氢质子磁共振波谱（1H-MRS）参数在预测胶质瘤免疫组化（IHC）生物标志物方面的性能：分析2015年3月至2019年9月经病理证实的胶质瘤患者，采集术前DTI和1H-MRS图像，测量病变区表观弥散系数（ADC）和各向异性分数（FA），通过病变区与对侧正常区的比值得出相对ADC（rADC）和相对FA（rFA）的相对值。1H-MRS 图像中病变区域的各代谢物峰值：N-乙酰天冬氨酸（NAA）、胆碱（Cho）和肌酸（Cr）以及代谢物比值：选择并计算 NAA/Cho、NAA/（Cho + Cr）代谢物比值。术前收集的 IHC 数据包括 CD34、Ki-67、p53、S-100、syn、波形蛋白、NeuN、Nestin 和胶质纤维酸性蛋白：筛选出一个 DTI 预测参数，Ki-67 阳性组的 rADC 低于阴性组。1H-MRS的两个参数对胶质瘤分级有重要参考价值，NAA和Cr随着胶质瘤分级的增加而降低，此外，Ki-67 Li与NAA和Cr呈负相关：结论：NAA和Cr在预测胶质瘤分级和肿瘤增殖活性方面具有潜在的应用价值。结论：NAA和Cr在预测胶质瘤分级和肿瘤增殖活性方面具有潜在的应用价值，而在DTI参数中，只有rADC对Ki-67的表达具有预测价值。

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来源期刊

Molecular Imaging Biochemistry, Genetics and Molecular Biology-Biotechnology

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3.60%

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期刊介绍： Molecular Imaging is a peer-reviewed, open access journal highlighting the breadth of molecular imaging research from basic science to preclinical studies to human applications. This serves both the scientific and clinical communities by disseminating novel results and concepts relevant to the biological study of normal and disease processes in both basic and translational studies ranging from mice to humans.