The influence of time-restricted eating/feeding on Alzheimer's biomarkers and gut microbiota.

IF 3.6 4区医学 Q2 NEUROSCIENCES Nutritional Neuroscience Pub Date : 2024-07-02 DOI:10.1080/1028415X.2024.2359868

Maha Gasmi, Novi Silvia Hardiany, Marie van der Merwe, Ian J Martins, Aastha Sharma, Ruth Williams-Hooker

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Abstract

Objectives: Alzheimer's disease (AD) is a progressive neurodegenerative disorder affecting approximately 55 million individuals globally. Diagnosis typically occurs in advanced stages, and there are limited options for reversing symptoms. Preventive strategies are, therefore, crucial. Time Restricted Eating (TRE) or Time Restricted Feeding (TRF) is one such strategy. Here we review recent research on AD and TRE/TRF in addition to AD biomarkers and gut microbiota.

Methods: A comprehensive review of recent studies was conducted to assess the impact of TRE/TRF on AD-related outcomes. This includes the analysis of how TRE/TRF influences circadian rhythms, beta-amyloid 42 (Aß42), pro-inflammatory cytokines levels, and gut microbiota composition.

Results: TRE/TRF impacts circadian rhythms and can influence cognitive performance as observed in AD. It lowers beta-amyloid 42 deposition in the brain, a key AD biomarker, and reduces pro-ininflammatory cytokines. The gut microbiome has emerged as a modifiable factor in AD treatment. TRE/TRF changes the structure and composition of the gut microbiota, leading to increased diversity and a decrease in harmful bacteria.

Discussion: These findings underscore the potential of TRE/TRF as a preventive strategy for AD. By reducing Aß42 plaques, modulating pro-inflammatory cytokines, and altering gut microbiota composition, TRE/TRF may slow the progression of AD. Further research is needed to confirm these effects and to understand the mechanisms involved. This review highlights TRE/TRF as a promising non-pharmacological intervention in the fight against AD.

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限时进食/喂食对阿尔茨海默氏症生物标志物和肠道微生物群的影响。

目的：阿尔茨海默病（AD）是一种渐进性神经退行性疾病，全球约有 5500 万人患病。该病通常在晚期才被诊断出来，而逆转症状的方法却很有限。因此，预防策略至关重要。限时进食（TRE）或限时喂食（TRF）就是这样一种策略。在此，我们回顾了有关AD和TRE/TRF以及AD生物标志物和肠道微生物群的最新研究：我们对近期研究进行了全面回顾，以评估 TRE/TRF 对注意力缺失症相关结果的影响。这包括分析TRE/TRF如何影响昼夜节律、β-淀粉样蛋白42（Aß42）、促炎细胞因子水平和肠道微生物群组成：结果：TRE/TRF影响昼夜节律，并能影响认知能力，这在AD中也能观察到。结果：TRE/TRF会影响昼夜节律，并能影响认知能力，正如在注意力缺失症中观察到的那样。它能降低大脑中β-淀粉样蛋白42的沉积（这是注意力缺失症的一个关键生物标志物），并减少促炎细胞因子。肠道微生物组已成为治疗注意力缺失症的一个可调节因素。TRE/TRF改变了肠道微生物群的结构和组成，从而增加了多样性，减少了有害细菌：这些发现强调了TRE/TRF作为AD预防策略的潜力。通过减少Aß42斑块、调节促炎细胞因子和改变肠道微生物群的组成，TRE/TRF可能会延缓AD的进展。要证实这些作用并了解其中的机制，还需要进一步的研究。本综述强调了 TRE/TRF 是一种很有前景的非药物干预措施，可用于抗击注意力缺失症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutritional Neuroscience 医学-神经科学

CiteScore

8.50

自引率

2.80%

发文量

236

审稿时长

>12 weeks

期刊介绍： Nutritional Neuroscience is an international, interdisciplinary broad-based, online journal for reporting both basic and clinical research in the field of nutrition that relates to the central and peripheral nervous system. Studies may include the role of different components of normal diet (protein, carbohydrate, fat, moderate use of alcohol, etc.), dietary supplements (minerals, vitamins, hormones, herbs, etc.), and food additives (artificial flavours, colours, sweeteners, etc.) on neurochemistry, neurobiology, and behavioural biology of all vertebrate and invertebrate organisms. Ideally this journal will serve as a forum for neuroscientists, nutritionists, neurologists, psychiatrists, and those interested in preventive medicine.