{"title":"Differences between sub-second and supra-second durations for the assessment of timing deficits in amnestic mild cognitive impairment","authors":"Giovanna Mioni , Thomas Wolbers , Martin Riemer","doi":"10.1016/j.nbas.2024.100120","DOIUrl":null,"url":null,"abstract":"<div><p>Previous studies have often reported timing deficits in older adults with different degrees of cognitive decline, however, the exact nature of impairments in time perception is still to be elucidated. In particular, it is unclear if the deficits are more pronounced for short or long intervals, consistent with notions that different cognitive processes and neuroanatomical areas are involved in the processing of durations of different ranges. The present study aims to further investigate timing abilities in amnestic mild cognitive impairment (aMCI) patients and age-matched controls. Participants were asked to decide whether an acoustic event occurred within the first or the second half of a reference duration. The results revealed a bias towards larger PSE values and reduced precision in aMCI patients compared to healthy controls. Further analyses showed that the bias towards larger PSE values correlated with memory performance, especially when sub-second durations were tested. Overall, the results demonstrate that memory deficits in aMCI patients coincide with changes in time perception in the sub-second interval range.</p></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":null,"pages":null},"PeriodicalIF":1.7000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589958924000161/pdfft?md5=afbf6637b9cc370465137a9693d2c29f&pid=1-s2.0-S2589958924000161-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Aging brain","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2589958924000161","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Previous studies have often reported timing deficits in older adults with different degrees of cognitive decline, however, the exact nature of impairments in time perception is still to be elucidated. In particular, it is unclear if the deficits are more pronounced for short or long intervals, consistent with notions that different cognitive processes and neuroanatomical areas are involved in the processing of durations of different ranges. The present study aims to further investigate timing abilities in amnestic mild cognitive impairment (aMCI) patients and age-matched controls. Participants were asked to decide whether an acoustic event occurred within the first or the second half of a reference duration. The results revealed a bias towards larger PSE values and reduced precision in aMCI patients compared to healthy controls. Further analyses showed that the bias towards larger PSE values correlated with memory performance, especially when sub-second durations were tested. Overall, the results demonstrate that memory deficits in aMCI patients coincide with changes in time perception in the sub-second interval range.
以往的研究经常报告不同程度认知衰退的老年人存在时间感知障碍,但时间感知障碍的确切性质仍有待阐明。特别是,目前还不清楚是短时间间隔还是长时间间隔的缺陷更明显,这与处理不同范围的持续时间涉及不同认知过程和神经解剖区域的观点是一致的。本研究旨在进一步调查失忆性轻度认知障碍(aMCI)患者和年龄匹配对照组的计时能力。研究人员要求受试者判断一个声音事件是发生在参考持续时间的前半部分还是后半部分。结果显示,与健康对照组相比,aMCI 患者的 PSE 值偏大,精确度降低。进一步的分析表明,偏向于较大的 PSE 值与记忆表现相关,尤其是在测试亚秒时长时。总之,研究结果表明,aMCI 患者的记忆缺陷与亚秒级时间间隔范围内时间感知的变化相吻合。