Low-Density lipoprotein cholesterol goal achievement and associated factors among type 2 diabetes mellitus patients at Tikur Anbessa Specialized Hospital in Addis Ababa, Ethiopia: Cross-sectional Study, 2023

Abdisa Beyene , Teshome Habte , Aklil Hailu
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Abstract

Background

Achieving the recommended low-density lipoprotein cholesterol goal is vital for managing cardiovascular risk. However, research on low-density lipoprotein cholesterol goal achievement and associated factors in Sub-Saharan Africa, particularly in Ethiopia, is limited. While global rates vary from 18% to 73%, there is a need for further investigation in this region to better understand and address the factors influencing low-density lipoprotein cholesterol goal attainment.

The objective was to assess low-density lipoprotein cholesterol goal achievement and associated factors among type 2 diabetes patients.

Methods

Institution based quantitative cross-sectional study design was conducted among type II diabetes patients at Tikur Anbessa Specialized Hospital in Addis Ababa, Ethiopia.

Systematic random sampling technique was used to select patient records. Data was collected by using a structured and pretested checklist and some variables were also collected from the chart review, structured questionnaire and analyzed using Epi info version 7.2 and SPSS version 25. Bivariate and multivariable logistic regressions were performed to examine the association between variables. Adjusted odds ratios (AOR) with 95 % confidence intervals were calculated, and a p-value of ≤ 0.05 was considered statistically significant for associations between independent and outcome variables.

Result

The LDL goal achievement among type II diabetes patients is 58.9 %.Total triglyceride level (AOR = 0.19, 95 %CI, 0.12, 0.54, P= <0.0001), history of smoking (AOR = 0.198, 95 %CI, 1.06, 1.10, P < 0.0001), 40–65 years of age (AOR = 0.21, 95 %CI, 0.05, 0.87, P = 0.03), BMI (AOR = 0.19, 95 %CI, 0.12, 0.54, P= <0.0001)., were found to be statistically significant independent predictors for LDL Goal Achievement in type II Diabetes patients.

Conclusion

In the current study, significant proportions of type II DM patients fail to attain acceptable levels of LDL cholesterol. Factors like total triglyceride levels, smoking history, older age, and increased BMI influenced low-density lipoprotein cholesterol goal achievement. Advanced in age, increase in BMI, smoking, and higher levels of triglyceride were determinants of LDL cholesterol goal achievement. Patient education on life style modification mainly cessation of smoking diet and exercise may be recommended to achieve the LDL cholesterol goal.

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埃塞俄比亚亚的斯亚贝巴 Tikur Anbessa 专科医院 2 型糖尿病患者的低密度脂蛋白胆固醇目标实现情况及相关因素:横断面研究,2023 年
背景实现推荐的低密度脂蛋白胆固醇目标对控制心血管风险至关重要。然而,在撒哈拉以南非洲地区,尤其是埃塞俄比亚,有关低密度脂蛋白胆固醇目标实现情况及相关因素的研究十分有限。方法在埃塞俄比亚亚的斯亚贝巴 Tikur Anbessa 专科医院的 II 型糖尿病患者中开展了一项基于机构的定量横断面研究,采用系统随机抽样技术选择患者病历。研究采用系统随机抽样技术选取患者病历,通过结构化和预先测试的核对表收集数据,还从病历审查和结构化问卷中收集了一些变量,并使用 Epi info 7.2 版和 SPSS 25 版进行了分析。对变量之间的关联进行了二元和多元逻辑回归分析。结果II型糖尿病患者的低密度脂蛋白目标达成率为58.9%。总甘油三酯水平(AOR = 0.19, 95 %CI, 0.12, 0.54, P=<0.0001)、吸烟史(AOR = 0.198, 95 %CI, 1.06, 1.10, P < 0.0001)、40-65 岁(AOR = 0.21, 95 %CI, 0.05, 0.87, P = 0.03)、体重指数(AOR = 0.19, 95 %CI, 0.12, 0.54, P= <0.0001)。结论 在目前的研究中,相当一部分 II 型糖尿病患者的低密度脂蛋白胆固醇达不到可接受的水平。总甘油三酯水平、吸烟史、高龄和体重指数增加等因素影响了低密度脂蛋白胆固醇目标的实现。高龄、体重指数增加、吸烟和甘油三酯水平较高是低密度脂蛋白胆固醇目标实现的决定因素。为实现低密度脂蛋白胆固醇目标,建议对患者进行以戒烟、饮食和运动为主的生活方式改变教育。
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来源期刊
CiteScore
2.40
自引率
0.00%
发文量
114
审稿时长
21 weeks
期刊介绍: International Journal of Africa Nursing Sciences (IJANS) is an international scientific journal published by Elsevier. The broad-based journal was founded on two key tenets, i.e. to publish the most exciting research with respect to the subjects of Nursing and Midwifery in Africa, and secondly, to advance the international understanding and development of nursing and midwifery in Africa, both as a profession and as an academic discipline. The fully refereed journal provides a forum for all aspects of nursing and midwifery sciences, especially new trends and advances. The journal call for original research papers, systematic and scholarly review articles, and critical papers which will stimulate debate on research, policy, theory or philosophy of nursing as related to nursing and midwifery in Africa, technical reports, and short communications, and which will meet the journal''s high academic and ethical standards. Manuscripts of nursing practice, education, management, and research are encouraged. The journal values critical scholarly debate on issues that have strategic significance for educators, practitioners, leaders and policy-makers of nursing and midwifery in Africa. The journal publishes the highest quality scholarly contributions reflecting the diversity of nursing, and is also inviting international scholars who are engaged with nursing and midwifery in Africa to contribute to the journal. We will only publish work that demonstrates the use of rigorous methodology as well as by publishing papers that highlight the theoretical underpinnings of nursing and midwifery as it relates to the Africa context.
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