Vaios D. Fytsilis , Miriam J.E. Urlings , Frederik-Jan van Schooten , Alie de Boer , Misha F. Vrolijk
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引用次数: 0
Abstract
The growing population and the associated increasing demand for high-protein meals are the main drivers of the protein transition. To meet demand, the food industry has turned to new technologies, such as food production through cell culture methods, also known as cellular agriculture. The interest in cellular agriculture is rising, and more products produced this way are seeking regulatory approval, including cell-based dairy products.
This review explores the potential toxicological challenges that may arise from cell-based dairy production, in regards to human consumption. The purpose is to identify knowledge gaps and elucidate an inscrutable field. The major production routes are described and analyzed regarding potential safety concerns and the current state of the industry. An in-depth look into the EU regulatory requirements concerning these foods is offered, along with a detailed overview of the potential risks and ways to assess them, focused on new approach methodologies (NAMs).
Cellular agriculture presents novel advantages and disadvantages in regard to food safety. To assess these novel risks, both regulatory and toxicological sciences need to adapt in order to keep up with innovations in food production. The advancement and integration of NAMs in food safety assessment is a crucial step to achieving this goal.
不断增长的人口和与之相关的对高蛋白膳食日益增长的需求是蛋白质转型的主要驱动力。为满足需求,食品工业已转向新技术,如通过细胞培养方法生产食品,也称为细胞农业。人们对细胞农业的兴趣日益高涨,越来越多以这种方式生产的产品正在寻求监管部门的批准,其中包括基于细胞的乳制品。本综述探讨了基于细胞的乳制品生产可能给人类消费带来的潜在毒理学挑战。本综述探讨了细胞乳制品生产在人类消费方面可能出现的潜在毒理学挑战,目的是找出知识差距,阐明这一难以捉摸的领域。就潜在的安全问题和行业现状对主要的生产途径进行了描述和分析。报告深入探讨了欧盟对这些食品的监管要求,并详细概述了潜在风险和评估风险的方法,重点介绍了新方法(NAMs)。为了评估这些新风险,监管科学和毒理学都需要进行调整,以跟上食品生产的创新步伐。在食品安全评估中推进和整合 NAM 是实现这一目标的关键一步。