{"title":"Testing for genomic biomarkers in non-small-cell lung cancer","authors":"Oliver G Shutkever, Philip Bennett, David A Moore","doi":"10.1016/j.mpdhp.2024.04.003","DOIUrl":null,"url":null,"abstract":"<div><p>The number of targeted therapies licenced for non-small cell lung cancer (NSCLC) has increased substantially in recent years, resulting in a major increase in demand for genomic testing of tissue specimens. The range of different alteration types that are now actionable in NSCLC is reflected in the complexity of current testing approaches. Cellular pathologists hold a key role in triaging tissue specimens for genomic biomarker testing and should be familiar with the genomic alterations seen in NSCLC, the testing strategies utilised and how to interpret molecular pathology reports in order to effectively support the management of NSCLC patients.</p></div>","PeriodicalId":39961,"journal":{"name":"Diagnostic Histopathology","volume":"30 7","pages":"Pages 362-370"},"PeriodicalIF":0.0000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diagnostic Histopathology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1756231724000513","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The number of targeted therapies licenced for non-small cell lung cancer (NSCLC) has increased substantially in recent years, resulting in a major increase in demand for genomic testing of tissue specimens. The range of different alteration types that are now actionable in NSCLC is reflected in the complexity of current testing approaches. Cellular pathologists hold a key role in triaging tissue specimens for genomic biomarker testing and should be familiar with the genomic alterations seen in NSCLC, the testing strategies utilised and how to interpret molecular pathology reports in order to effectively support the management of NSCLC patients.
期刊介绍：
This monthly review journal aims to provide the practising diagnostic pathologist and trainee pathologist with up-to-date reviews on histopathology and cytology and related technical advances. Each issue contains invited articles on a variety of topics from experts in the field and includes a mini-symposium exploring one subject in greater depth. Articles consist of system-based, disease-based reviews and advances in technology. They update the readers on day-to-day diagnostic work and keep them informed of important new developments. An additional feature is the short section devoted to hypotheses; these have been refereed. There is also a correspondence section.
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