Effect of combining batroxobin with acupuncture treatment on hearing recovery in patients with sudden sensorineural hearing loss.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-04-01 Epub Date: 2024-07-02 DOI:10.1080/00016489.2024.2369295

XiaoYan Le, JingJing Liu, QiaoFei Jia, JiaYuan Wu, YiZhen Jiang, ZhengGang Lv

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Abstract

Background: The effect of batroxobin on hearing recovery in patients with Sudden Sensorineural Hearing Loss (SSNHL) is still controversial, and acupuncture shows auxiliary benefits for SSNHL.

Objectives: To investigate the effectiveness of combining acupuncture with batroxobin therapy for patients with SSNHL.

Material and methods: One hundred and fifty-six patients with SSNHL were retrospectively enrolled in this study, and categorized into the control group (only batroxobin treatment) and observation group (batroxobin and acupuncture treatment). Pure Tone Audiograms (PTA) threshold and clinical outcomes of hearing recovery were compared. Logistic regression analysis was used to evaluate the association between hearing recovery and potential risk factors.

Results: Compared to the control group, the observation group had a higher overall effective rate (p = 0.006) and improvement in PTA threshold (p = 0.007). Among SSNHL patients with high-frequency and flat-type hearing loss, observation group demonstrated superior hearing recovery post-treatment compared to the control group (p < 0.05). Additionally, hearing recovery in patient with SSNHL were associated with SSNHL types, disease duration, neutrophil count and acupuncture (p < 0.05).

Conclusions and significance: Combining batroxobin and acupuncture treatments enhences the improvement of hearing recovery in SSNHL patients compared to only batroxobin treatments, especially high-frequency and flat-type hearing loss.

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巴曲霉素联合针灸治疗对突发性感音神经性听力损失患者听力恢复的影响

背景：巴曲溴铵对突发性感音神经性听力损失（SSNHL）患者听力恢复的影响仍存在争议，而针灸对SSNHL有辅助疗效：研究针灸与巴曲霉素联合治疗对 SSNHL 患者的疗效：回顾性纳入 156 例 SSNHL 患者，分为对照组（仅接受巴曲酶治疗）和观察组（接受巴曲酶和针灸治疗）。比较了纯音听力图（PTA）阈值和听力恢复的临床结果。采用逻辑回归分析评估听力恢复与潜在风险因素之间的关系：结果：与对照组相比，观察组的总有效率更高（P = 0.006），PTA阈值也有所提高（P = 0.007）。在高频和平型听力损失的 SSNHL 患者中，观察组治疗后的听力恢复优于对照组（p p 结论和意义：与仅使用巴曲霉素治疗相比，联合使用巴曲霉素和针灸治疗可改善 SSNHL 患者的听力恢复，尤其是高频和平型听力损失。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.