Systemic Therapy for Non-Melanoma Skin Cancers: Latest Advances.

IF 4.7 2区 医学 Q1 ONCOLOGY Current Oncology Reports Pub Date : 2024-09-01 Epub Date: 2024-07-02 DOI:10.1007/s11912-024-01570-1
Spencer Lessans, Katie A O'Connell, Jennifer Choe
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Abstract

Purpose of review: This review provides an update on approved and emerging systemic therapies in the treatment of locally advanced or metastatic non-melanoma skin cancers (squamous cell carcinoma, basal cell carcinoma, Merkel cell carcinoma).

Recent findings: Many studies demonstrate the effectiveness of immunotherapy for all types of non-melanoma skin cancer. For basal cell carcinoma (BCC), hedgehog inhibitors (HHI) remain first-line but with poor tolerability. Numerous clinical trials studying both neoadjuvant and adjuvant use of anti-PD-1 and anti-PD-L1 therapies in advanced NMSC are under investigation. There is a growing number of systemic therapies available to treat non-melanoma skin cancers. The advent of immunotherapy has revolutionized the field and greatly improved survival compared to historical survival rates with cytotoxic chemotherapy.

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非黑色素瘤皮肤癌的系统疗法:最新进展。
综述目的:本综述介绍了在治疗局部晚期或转移性非黑色素瘤皮肤癌(鳞状细胞癌、基底细胞癌、梅克尔细胞癌)方面已获批准的和新出现的系统疗法的最新情况:许多研究表明,免疫疗法对所有类型的非黑色素瘤皮肤癌都很有效。对于基底细胞癌(BCC),刺猬抑制剂(HHI)仍是一线治疗药物,但耐受性较差。许多临床试验正在研究抗PD-1和抗PD-L1疗法在晚期非黑素瘤皮肤癌中的新辅助治疗和辅助治疗。治疗非黑色素瘤皮肤癌的系统疗法越来越多。免疫疗法的出现彻底改变了这一领域,与细胞毒化疗的历史生存率相比,免疫疗法大大提高了生存率。
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来源期刊
CiteScore
8.50
自引率
0.00%
发文量
187
审稿时长
6-12 weeks
期刊介绍: This journal aims to review the most important, recently published clinical findings in the field of oncology. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care of those affected by cancer. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as cancer prevention, leukemia, melanoma, neuro-oncology, and palliative medicine. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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