Correlation between lipoprotein-associated phospholipase A2 and poststroke mild cognitive impairment.

IF 3.9 3区医学 Q1 PATHOLOGY Expert Review of Molecular Diagnostics Pub Date : 2024-06-01 Epub Date: 2024-07-03 DOI:10.1080/14737159.2024.2370410

Yawei Cao, Xiaofeng Zhu, Jin Shang, Jinlong Zheng, Xiangyang Tian, Qiu Han, Jun Shen

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Abstract

Objectives: This study aimed to investigate the correlation between serum lipoprotein-associated phospholipase A2 (Lp-PLA2) and poststroke mild cognitive impairment (PSMCI).

Methods: The patients included in the study were divided into PSMCI (68 cases) and cognitively normal (CN) (218 cases) groups and followed up for six months. Demographic and clinical data were collected. A logistic regression analysis was performed to determine whether Lp-PLA2 is an independent risk factor for PSMCI. Spearman's correlation analysis was used to examine the correlation between Lp-PLA2 levels and Montreal Cognitive Assessment (MoCA) scores. A receiver operating characteristic (ROC) curve analysis was performed to determine the diagnostic threshold value of Lp-PLA2 for PSMCI.

Results: Serum Lp-PLA2 levels were significantly higher in the PSMCI group than in the CN group. The logistic regression analysis showed that Lp-PLA2 was an independent risk factor for PSMCI (OR = 1.05, 95% CI = 1.03-1.07). Spearman's correlation analysis revealed a significant correlation between the Lp-PLA2 levels and MoCA scores (R = -0.49). The area under the ROC curve for Lp-PLA2 was 0.849, and the threshold value for PSMCI occurrence was 236.8 ng/ml.

Conclusions: Elevated serum Lp-PLA2 is an independent risk factor for PSMCI and may serve as a potential biomarker for PSMCI.

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脂蛋白相关磷脂酶 A2 与脑卒中后轻度认知障碍之间的相关性。

研究目的本研究旨在探讨血清脂蛋白相关磷脂酶A2（Lp-PLA2）与脑卒中后轻度认知障碍（PSMCI）之间的相关性：方法：将患者分为 PSMCI 组（68 例）和认知功能正常组（218 例），随访 6 个月。收集了人口统计学和临床数据。研究人员进行了逻辑回归分析，以确定 Lp-PLA2 是否是 PSMCI 的独立风险因素。斯皮尔曼相关分析用于研究 Lp-PLA2 水平与蒙特利尔认知评估（MoCA）评分之间的相关性。为了确定脂蛋白-PLA2对PSMCI的诊断阈值，进行了接收者操作特征（ROC）曲线分析：结果：PSMCI 组血清 Lp-PLA2 水平明显高于 CN 组。逻辑回归分析显示，Lp-PLA2 是 PSMCI 的独立危险因素（OR = 1.05，95% CI = 1.03-1.07）。斯皮尔曼相关分析显示，Lp-PLA2 水平与 MoCA 评分之间存在显著相关性（R = -0.49）。Lp-PLA2 的 ROC 曲线下面积为 0.849，PSMCI 发生的临界值为 236.8 纳克/毫升：结论：血清 Lp-PLA2 升高是 PSMCI 的独立危险因素，可作为 PSMCI 的潜在生物标志物。

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来源期刊

Expert Review of Molecular Diagnostics 医学-病理学

CiteScore

6.60

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Expert Review of Molecular Diagnostics (ISSN 1473-7159) publishes expert reviews of the latest advancements in the field of molecular diagnostics including the detection and monitoring of the molecular causes of disease that are being translated into groundbreaking diagnostic and prognostic technologies to be used in the clinical diagnostic setting. Each issue of Expert Review of Molecular Diagnostics contains leading reviews on current and emerging topics relating to molecular diagnostics, subject to a rigorous peer review process; editorials discussing contentious issues in the field; diagnostic profiles featuring independent, expert evaluations of diagnostic tests; meeting reports of recent molecular diagnostics conferences and key paper evaluations featuring assessments of significant, recently published articles from specialists in molecular diagnostic therapy. Expert Review of Molecular Diagnostics provides the forum for reporting the critical advances being made in this ever-expanding field, as well as the major challenges ahead in their clinical implementation. The journal delivers this information in concise, at-a-glance article formats: invaluable to a time-constrained community.