Recent advances in understanding of the mechanisms of RNA interference in insects.

IF 2.3 2区农林科学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Insect Molecular Biology Pub Date : 2024-07-03 DOI:10.1111/imb.12941

Jinmo Koo, Subba Reddy Palli

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Abstract

We highlight the recent 5 years of research that contributed to our understanding of the mechanisms of RNA interference (RNAi) in insects. Since its first discovery, RNAi has contributed enormously as a reverse genetic tool for functional genomic studies. RNAi is also being used in therapeutics, as well as agricultural crop and livestock production and protection. Yet, for the wider application of RNAi, improvement of its potency and delivery technologies is needed. A mechanistic understanding of every step of RNAi, from cellular uptake of RNAi trigger molecules to targeted mRNA degradation, is key for developing an efficient strategy to improve RNAi technology. Insects provide an excellent model for studying the mechanism of RNAi due to species-specific variations in RNAi efficiency. This allows us to perform comparative studies in insect species with different RNAi sensitivity. Understanding the mechanisms of RNAi in different insects can lead to the development of better strategies to improve RNAi and its application to manage agriculturally and medically important insects.

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了解昆虫 RNA 干扰机制的最新进展。

我们重点介绍了最近五年来有助于我们了解昆虫 RNA 干扰（RNAi）机制的研究。自首次发现以来，RNAi 作为一种反向遗传工具为功能基因组研究做出了巨大贡献。RNAi 还被用于治疗以及农作物和牲畜的生产和保护。然而，要使 RNAi 得到更广泛的应用，还需要改进其效力和传递技术。从机理上理解 RNAi 的每一个步骤，从细胞摄取 RNAi 触发分子到靶向 mRNA 降解，是开发有效战略以改进 RNAi 技术的关键。昆虫是研究 RNAi 机制的绝佳模型，因为 RNAi 效率存在物种特异性差异。这使我们能够对具有不同 RNAi 敏感性的昆虫物种进行比较研究。了解不同昆虫的 RNAi 机制可以开发出更好的 RNAi 改进策略，并将其应用于管理重要的农业和医学昆虫。

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来源期刊

Insect Molecular Biology 生物-昆虫学

CiteScore

4.80

自引率

3.80%

发文量

审稿时长

6-12 weeks

期刊介绍： Insect Molecular Biology has been dedicated to providing researchers with the opportunity to publish high quality original research on topics broadly related to insect molecular biology since 1992. IMB is particularly interested in publishing research in insect genomics/genes and proteomics/proteins. This includes research related to: • insect gene structure • control of gene expression • localisation and function/activity of proteins • interactions of proteins and ligands/substrates • effect of mutations on gene/protein function • evolution of insect genes/genomes, especially where principles relevant to insects in general are established • molecular population genetics where data are used to identify genes (or regions of genomes) involved in specific adaptations • gene mapping using molecular tools • molecular interactions of insects with microorganisms including Wolbachia, symbionts and viruses or other pathogens transmitted by insects Papers can include large data sets e.g.from micro-array or proteomic experiments or analyses of genome sequences done in silico (subject to the data being placed in the context of hypothesis testing).