Prostanoid signaling in retinal vascular diseases

IF 2.5 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Prostaglandins & other lipid mediators Pub Date : 2024-06-30 DOI:10.1016/j.prostaglandins.2024.106864

Amy K. Stark , John S. Penn

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Abstract

The vasculature of the retina is exposed to systemic and local factors that have the capacity to induce several retinal vascular diseases, each of which may lead to vision loss. Prostaglandin signaling has arisen as a potential therapeutic target for several of these diseases due to the diverse manners in which these lipid mediators may affect retinal blood vessel function. Previous reports and clinical practices have investigated cyclooxygenase (COX) inhibition by nonsteroidal anti-inflammatory drugs (NSAIDs) to address retinal diseases with varying degrees of success; however, targeting individual prostanoids or their distinct receptors affords more signaling specificity and poses strong potential for therapeutic development. This review offers a comprehensive view of prostanoid signaling involved in five key retinal vascular diseases: retinopathy of prematurity, diabetic retinopathy, age-related macular degeneration, retinal occlusive diseases, and uveitis. Mechanistic and clinical studies of these lipid mediators provide an outlook for therapeutic development with the potential to reduce vision loss in each of these conditions.

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视网膜血管疾病中的类固醇信号转导。

视网膜血管受到全身和局部因素的影响，这些因素有可能诱发多种视网膜血管疾病，每种疾病都可能导致视力丧失。前列腺素信号传导已成为其中几种疾病的潜在治疗靶点，因为这些脂质介质可能以多种方式影响视网膜血管功能。以前的报告和临床实践研究了通过非甾体抗炎药（NSAIDs）抑制环氧化酶（COX）来治疗视网膜疾病，并取得了不同程度的成功；然而，靶向单个前列腺素或其不同的受体可提供更多的信号特异性，并为治疗开发带来巨大潜力。本综述全面介绍了涉及五种主要视网膜血管疾病的前列腺素信号传导：早产儿视网膜病变、糖尿病视网膜病变、老年性黄斑变性、视网膜闭塞性疾病和葡萄膜炎。对这些脂质介质的机制和临床研究为治疗方法的开发提供了前景，这些治疗方法有可能减少上述每种疾病的视力损失。

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来源期刊

Prostaglandins & other lipid mediators 生物-生化与分子生物学

CiteScore

5.80

自引率

3.40%

发文量

审稿时长

2 months

期刊介绍： Prostaglandins & Other Lipid Mediators is the original and foremost journal dealing with prostaglandins and related lipid mediator substances. It includes basic and clinical studies related to the pharmacology, physiology, pathology and biochemistry of lipid mediators. Prostaglandins & Other Lipid Mediators invites reports of original research, mini-reviews, reviews, and methods articles in the basic and clinical aspects of all areas of lipid mediator research: cell biology, developmental biology, genetics, molecular biology, chemistry, biochemistry, physiology, pharmacology, endocrinology, biology, the medical sciences, and epidemiology. Prostaglandins & Other Lipid Mediators also accepts proposals for special issue topics. The Editors will make every effort to advise authors of the decision on the submitted manuscript within 3-4 weeks of receipt.