A multicenter protocol to assess the prognostic significance of the tumor microenvironment in patients with squamous cell carcinoma of the larynx

IF 2.3 3区医学 Q1 OTORHINOLARYNGOLOGY Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2024-07-03 DOI:10.1002/hed.27860

Pietro De Luca MD, Arianna Di Stadio MD, PhD, Gerardo Petruzzi MD, Luca de Campora MD, PhD, Milena Fior MD, Claudio Moretti MD, Vincenzo Della Peruta MD, Francesco Mazzola MD, Leopoldo Costarelli MD, Renato Covello MD, Filippo Ricciardiello MD, Giuseppe Tortoriello MD, Raul Pellini MD, Marco Radici MD, Angelo Camaioni MD

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Abstract

Background

The purpose of this multicenter study was to retrospectively investigate the prognostic significance of the tumor microenvironment, in relation to survival in a large cohort of patients with laryngeal squamous cell carcinoma (LSCC), using the method proposed by the International TILs Working Group in breast cancer.

Methods

All consecutive patients with biopsy-proven LSCC who underwent total laryngectomy (TL) between January 2014 and January 2023 were retrospectively included in the study. A retrospective review of medical records including surgical, pathological and follow-up reports was performed. The density of TILs was determined according to the recommendations of the International TILs Working Group.

Results

The study group included 186 patients with LSCC. High TILs were statistically correlated with reduced size and extension of primary tumor (pT stage) with a statistically significant value (S: p = 0.01; P: p = 0.0003) and without needs of salvage therapy (S: p = 0.03; P: p = 0.004). Low TILs were indicative of worse prognosis.

Conclusions

Our study confirmed the protective value of TILs and the prognostic role of the tumor microenvironment in LSCC; furthermore, our results showed that the score proposed by the International TILs Working Group for breast cancer can be applied to LSCC.

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一项评估喉鳞状细胞癌患者肿瘤微环境预后意义的多中心方案。

研究背景这项多中心研究的目的是采用国际乳腺癌TILs工作组提出的方法，回顾性研究肿瘤微环境对一大批喉鳞状细胞癌（LSCC）患者生存期的预后意义：回顾性纳入2014年1月至2023年1月期间接受全喉切除术（TL）的所有经活检证实的LSCC连续患者。研究人员对包括手术、病理和随访报告在内的医疗记录进行了回顾性审查。TILs的密度根据国际TILs工作组的建议确定：研究组包括 186 名 LSCC 患者。高TILs与原发肿瘤的缩小和扩展（pT分期）有统计学意义（S：P = 0.01；P：P = 0.0003），且不需要挽救治疗（S：P = 0.03；P：P = 0.004）。低TILs表明预后较差：我们的研究证实了TILs的保护价值以及肿瘤微环境在LSCC中的预后作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.