Trends in obstructive sleep apnea disease severity over nearly two decades: update on the VA San Diego experience.

Brandon Nokes, Tania Zamora, Yzabel Velazquez, Shah Golshan, Cesar Cervantes-Gomeros, Will Perrine, Robert Barker, Atul Malhotra, Kathleen F Sarmiento, Carl Stepnowsky
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Abstract

Study objectives: The Sleep Program at the VA San Diego Healthcare System (VASDHS) started a patient database over twenty years ago for its home sleep apnea testing (HSAT) program. An analysis of ten years of diagnostic HSAT data was reported on over 12 500 patients in 2014. Over this time period, severe obstructive sleep apnea (OSA) decreased in frequency. In contrast, mild OSA increased in frequency and was the most frequently reported severity in our analysis. In more recent times, the 2021 continuous positive airway pressure (CPAP) crisis created difficulties in dispersing CPAP therapies to individuals including Veterans with OSA, prompting our group to reexamine the HSAT database.

Methods: A retrospective review was performed of the local clinical database of HSAT diagnostic testing of 8,928 sleep studies from 2018 to 2022.

Results: The overall mean apnea-hypopnea index (AHI) decreased from 40.4/hour (2004) to 24.3/hour (2022) (p < .001). The two time periods were examined separately. For 2004-2013, it was found that the mean AHI in 2004 was not significantly different from the mean AHI in 2005, 2006, or 2007 but was significantly different from the mean AHI in each year from 2008 (mean AHI = 30.7/h) to 2013 (mean AHI = 26.1/hour). For 2019-2022, the mean AHI did not significantly differ between the 4 years.

Conclusions: These findings have implications for OSA therapies. Additionally, the high prevalence of mild sleep apnea, which is typically associated with lesser adherence to PAP therapy, further highlights the importance of non-PAP alternatives to improve treatment effectiveness.

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近二十年来阻塞性睡眠呼吸暂停疾病严重程度的变化趋势:圣地亚哥退伍军人事务部的最新经验。
研究目的:退伍军人圣地亚哥医疗保健系统(VASDHS)的睡眠项目早在二十多年前就开始为其家庭睡眠呼吸检测(HSAT)项目建立患者数据库。2014 年,对超过 12 500 名患者的十年 HSAT 诊断数据进行了分析。在此期间,重度阻塞性睡眠呼吸暂停(OSA)的发生率有所下降。相比之下,轻度阻塞性睡眠呼吸暂停(OSA)的发生率有所上升,是我们分析中最常报告的严重程度。最近,2021 年的持续气道正压(CPAP)危机给向包括患有 OSA 的退伍军人在内的个人提供 CPAP 治疗造成了困难,促使我们的研究小组重新审查 HSAT 数据库:我们对当地的 HSAT 诊断测试临床数据库中 2018 年至 2022 年的 8928 项睡眠研究进行了回顾性审查:总体平均呼吸暂停-低通气指数(AHI)从40.4/小时(2004年)下降到24.3/小时(2022年)(p 结论:这些结果对OSA的治疗具有重要意义:这些发现对 OSA 的治疗具有重要意义。此外,轻度睡眠呼吸暂停的发病率较高,而轻度睡眠呼吸暂停通常与呼吸机治疗的依从性较差有关,这进一步凸显了非呼吸机治疗对提高治疗效果的重要性。
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