Changting Wen , Guojin Sun , Lang Liu , Jun Zhang , Mengyao She , Zheng Yang , Ping Liu , Shengyong Zhang , Jianli Li
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引用次数: 0
Abstract
Thiadiazole and selenadiazole derivatives are significant organic backbones widely utilized in drugs, bioactive molecules, and functional materials. A green and efficient one-pot synthetic methodology has been developed for the fabrication of thiadiazole/selenadiazole derivatives, which involves photocatalytic induced iodine substitution, oxydic aldehyde formation, and nucleophilic addition, resulting in C–S bond formation and hydrazylation, cyclization, and rearrangement, as well as dehydration. The present method includes good functional group tolerance, simple, mild, metal-free, and safe conditions that are in line with the principles of green chemistry, making this protocol an attractive strategy for the synthesis of bioactive molecules with thiadiazole/selenadiazole frameworks. Gratifyingly, the complanate and conjugate structures of the synthesized compounds ensured attractive fluorescent properties for successful application in biological cell imaging.
期刊介绍:
Green Chemistry is a journal that provides a unique forum for the publication of innovative research on the development of alternative green and sustainable technologies. The scope of Green Chemistry is based on the definition proposed by Anastas and Warner (Green Chemistry: Theory and Practice, P T Anastas and J C Warner, Oxford University Press, Oxford, 1998), which defines green chemistry as the utilisation of a set of principles that reduces or eliminates the use or generation of hazardous substances in the design, manufacture and application of chemical products. Green Chemistry aims to reduce the environmental impact of the chemical enterprise by developing a technology base that is inherently non-toxic to living things and the environment. The journal welcomes submissions on all aspects of research relating to this endeavor and publishes original and significant cutting-edge research that is likely to be of wide general appeal. For a work to be published, it must present a significant advance in green chemistry, including a comparison with existing methods and a demonstration of advantages over those methods.