Risk factors for uveitis in a Finnish sarcoid population.

IF 3 3区医学 Q1 OPHTHALMOLOGY Acta Ophthalmologica Pub Date : 2024-07-04 DOI:10.1111/aos.16738

Elli Joukainen, Jaakko Antonen, Sanna Leinonen

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Abstract

Purpose: To evaluate possible risk factors for uveitis among Finnish sarcoidosis patients.

Methods: Patient charts of patients with sarcoidosis, with (n = 97) or without (n = 255) uveitis, and with a comprehensive eye examination from January 2014 to January 2021 at Tays Eye Centre, Tampere University Hospital, Finland were studied.

Results: Sarcoidosis patients with uveitis had higher rate of lymphocytopenia (43% vs. 29%, p = 0.041) and lower serum lysozyme levels (2.0 mg/L vs. 2.3 mg/L, p = 0.049; 95% CI, -0.692 to -0.002). Lysozyme level or lymphocytopenia did not have a statistically significant effect on the probability of uveitis in a binary logistic regression analysis. No other differences in the potential risk factors with p-values ≤0.05 were found, including bilateral hilar lymphadenopathy, serum angiotensin-converting enzyme (ACE) levels, sex, age and history of smoking.

Conclusion: Lymphocytopenia and lower serum lysozyme levels present as possible risk factors for uveitis among patients with sarcoidosis. Systematic measurement of lymphocyte and lysozyme levels in sarcoidosis is needed to further understand their role as potential risk factors.

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芬兰肉瘤人群中葡萄膜炎的风险因素。

目的：评估芬兰肉样瘤病患者患葡萄膜炎的可能风险因素：研究对象为2014年1月至2021年1月期间在芬兰坦佩雷大学医院泰斯眼科中心接受过全面眼科检查的肉样瘤病患者病历，其中包括葡萄膜炎患者（97人）或无葡萄膜炎患者（255人）：结果：患有葡萄膜炎的肉样瘤患者淋巴细胞减少率较高（43% 对 29%，p = 0.041），血清溶菌酶水平较低（2.0 mg/L 对 2.3 mg/L，p = 0.049；95% CI，-0.692 至 -0.002）。在二元逻辑回归分析中，溶菌酶水平或淋巴细胞减少症对葡萄膜炎的概率没有统计学意义。P值≤0.05的潜在风险因素中没有发现其他差异，包括双侧肺门淋巴结病、血清血管紧张素转换酶（ACE）水平、性别、年龄和吸烟史：结论：淋巴细胞减少和血清溶菌酶水平降低可能是肉样瘤病患者患葡萄膜炎的危险因素。需要对肉样瘤病患者的淋巴细胞和溶菌酶水平进行系统测量，以进一步了解它们作为潜在风险因素的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Ophthalmologica 医学-眼科学

CiteScore

7.60

自引率

5.90%

发文量

433

审稿时长

6 months

期刊介绍： Acta Ophthalmologica is published on behalf of the Acta Ophthalmologica Scandinavica Foundation and is the official scientific publication of the following societies: The Danish Ophthalmological Society, The Finnish Ophthalmological Society, The Icelandic Ophthalmological Society, The Norwegian Ophthalmological Society and The Swedish Ophthalmological Society, and also the European Association for Vision and Eye Research (EVER). Acta Ophthalmologica publishes clinical and experimental original articles, reviews, editorials, educational photo essays (Diagnosis and Therapy in Ophthalmology), case reports and case series, letters to the editor and doctoral theses.