FOXM1 transcriptional regulation

IF 2.4 4区生物学 Q4 CELL BIOLOGY Biology of the Cell Pub Date : 2024-07-04 DOI:10.1111/boc.202400012

Mengxi Li, Xuzheng Gao, Yanting Su, Shigang Shan, Wenbin Qian, Zhenwang Zhang, Dan Zhu

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Abstract

FOXM1 is a key transcriptional regulator involved in various biological processes in mammals, including carbohydrate and lipid metabolism, aging, immune regulation, development, and disease. Early studies have shown that FOXM1 acts as an oncogene by regulating cell proliferation, cell cycle, migration, metastasis, and apoptosis, as well as genes related to diagnosis, treatment, chemotherapy resistance, and prognosis. Researchers are increasingly focusing on FOXM1 functions in tumor microenvironment, epigenetics, and immune infiltration. However, researchers have not comprehensively described FOXM1's involvement in tumor microenvironment shaping, epigenetics, and immune cell infiltration. Here we review the role of FOXM1 in the formation and development of malignant tumors, and we will provide a comprehensive summary of the role of FOXM1 in transcriptional regulation, interacting proteins, tumor microenvironment, epigenetics, and immune infiltration, and suggest areas for further research.

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FOXM1 转录调控。

FOXM1 是一种关键的转录调节因子，参与哺乳动物的各种生物过程，包括碳水化合物和脂质代谢、衰老、免疫调节、发育和疾病。早期研究表明，FOXM1 通过调节细胞增殖、细胞周期、迁移、转移和凋亡，以及与诊断、治疗、化疗抗性和预后相关的基因，起到癌基因的作用。研究人员越来越关注 FOXM1 在肿瘤微环境、表观遗传学和免疫浸润方面的功能。然而，研究人员尚未全面描述 FOXM1 在肿瘤微环境塑造、表观遗传学和免疫细胞浸润中的参与。在此，我们回顾了 FOXM1 在恶性肿瘤形成和发展中的作用，并将全面总结 FOXM1 在转录调控、互作蛋白、肿瘤微环境、表观遗传学和免疫浸润中的作用，并提出有待进一步研究的领域。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biology of the Cell 生物-细胞生物学

CiteScore

5.30

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The journal publishes original research articles and reviews on all aspects of cellular, molecular and structural biology, developmental biology, cell physiology and evolution. It will publish articles or reviews contributing to the understanding of the elementary biochemical and biophysical principles of live matter organization from the molecular, cellular and tissues scales and organisms. This includes contributions directed towards understanding biochemical and biophysical mechanisms, structure-function relationships with respect to basic cell and tissue functions, development, development/evolution relationship, morphogenesis, stem cell biology, cell biology of disease, plant cell biology, as well as contributions directed toward understanding integrated processes at the organelles, cell and tissue levels. Contributions using approaches such as high resolution imaging, live imaging, quantitative cell biology and integrated biology; as well as those using innovative genetic and epigenetic technologies, ex-vivo tissue engineering, cellular, tissue and integrated functional analysis, and quantitative biology and modeling to demonstrate original biological principles are encouraged.

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