Characterization of Mild Delayed Gestational Hypertension in Rats Following Ozone Exposure.

IF 3.4 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Cardiovascular Toxicology Pub Date : 2024-09-01 Epub Date: 2024-07-04 DOI:10.1007/s12012-024-09887-w
Russell Hunter, Thomas Wilson, Selita Lucas, David Scieszka, Barry Bleske, Andrew Ottens, Ryan Ashley, Carolyn Pace, Nancy Kanagy, Matthew Campen
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Abstract

The contribution of air pollution-induced cardiopulmonary damage on the development of hypertensive disorders of pregnancy and other adverse outcomes of pregnancy has gained increased attention as epidemiological data continue to highlight spatiotemporal pregnancy trends related to air pollution exposure. However clinical mechanistic data surrounding gestational complications remain sparse, necessitating the need for the use of animal models to study these types of complications of pregnancy. The current study seeks to examine the real-time effects of mid-gestational ozone exposure on maternal blood pressure and body temperature through the use of radiotelemetry in a rat model. The exposure resulted in acute depression of heart rate and core body temperature as compared to control animals. Ozone-exposed animals also presented with a slight but significant increase in arterial blood pressure which was perpetuated until term. The data presented here illustrates the feasibility of murine models to assess cardiovascular complications caused by inhaled toxicants during the window of pregnancy.

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臭氧暴露后大鼠轻度延迟性妊娠高血压的特征。
随着流行病学数据不断突显出与空气污染暴露相关的妊娠时空趋势,空气污染诱发的心肺损伤对妊娠高血压疾病和其他不良妊娠结局的发生所起的作用日益受到关注。然而,有关妊娠并发症的临床机理数据仍然很少,因此有必要使用动物模型来研究这类妊娠并发症。目前的研究试图通过在大鼠模型中使用放射性遥测技术,研究妊娠中期臭氧暴露对母体血压和体温的实时影响。与对照组动物相比,接触臭氧会导致心率和核心体温急性下降。接触臭氧的动物动脉血压也会出现轻微但显著的升高,这种情况一直持续到分娩。本文提供的数据表明,用小鼠模型来评估妊娠期吸入有毒物质引起的心血管并发症是可行的。
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来源期刊
Cardiovascular Toxicology
Cardiovascular Toxicology 医学-毒理学
CiteScore
6.60
自引率
3.10%
发文量
61
审稿时长
>12 weeks
期刊介绍: Cardiovascular Toxicology is the only journal dedicated to publishing contemporary issues, timely reviews, and experimental and clinical data on toxicological aspects of cardiovascular disease. CT publishes papers that will elucidate the effects, molecular mechanisms, and signaling pathways of environmental toxicants on the cardiovascular system. Also covered are the detrimental effects of new cardiovascular drugs, and cardiovascular effects of non-cardiovascular drugs, anti-cancer chemotherapy, and gene therapy. In addition, Cardiovascular Toxicology reports safety and toxicological data on new cardiovascular and non-cardiovascular drugs.
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