Effects of variation in exercise training load on cognitive performances and neurotrophic biomarkers in patients with coronary artery disease.

IF 3.3 3区 医学 Q1 PHYSIOLOGY Journal of applied physiology Pub Date : 2024-11-01 Epub Date: 2024-07-04 DOI:10.1152/japplphysiol.00636.2023
Maxime Boidin, Catherine-Alexandra Grégoire, Christine Gagnon, Nathalie Thorin-Trescases, Eric Thorin, Anil Nigam, Martin Juneau, Arthur Guillaume, Jonathan Tremblay, Mathieu Gayda, Louis Bherer
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Abstract

This study compared the effects of linear (LP) and nonlinear (NLP) training periodization on cognitive functions, neurotrophic biomarkers [plasma brain-derived neurotrophic factor (BDNF), insulin-like growth factor-1 (IGF-1)], and cathepsin-B in patients with coronary artery disease (CAD). Forty-four patients with CAD reported to our laboratory on two occasions to undergo testing procedures before and after training sessions, and were then blindly randomized to NLP or LP for 36 training sessions. Visit 1 included blood samples and a maximal cardiopulmonary exercise testing to get maximal oxygen uptake (V̇o2peak). Visit 2 included cognitive functions assessment. Thirty-nine patients completed the study (LP: n = 20, NLP: n = 19), with no observed changes in cognitive performances after the training intervention in either group. IGF-1 concentration decreased in both groups (time-effect: P < 0.001), whereas BDNF concentration increased (time-effect: P < 0.05) without group interaction, and cathepsin-B did not change after the intervention. Associations were found between ΔV̇o2peak and ΔBDNF (R2 = 0.18, P = 0.04), and ΔIGF-1 and Δshort-term/working memory (R2 = 0.17, P = 0.01) in the pooled sample, with ΔIGF-1 and ΔBDNF accounting for 10% of the variance in Δshort-term/working memory. In the LP group, associations were found between ΔV̇o2peak and ΔBDNF (R2 = 0.45, P = 0.02), ΔBDNF and Δshort-term/working memory (R2 = 0.62, P = 0.004), ΔIGF-1 and Δshort-term/working memory (R2 = 0.31, P = 0.01), and ΔIGF-1 and Δexecutive function (R2 = 0.22, P = 0.04). This study indicates that linear and nonlinear training periodization led to an increase in BDNF, and a decrease in IGF-1, without change in cognitive function in individuals with stable CAD.NEW & NOTEWORTHY We used a novel and supervised iso-energetic training, integrating both moderate- and high-intensity aerobic exercises. Our findings indicate that greater variation in training load did not yield cognitive enhancements, although both protocols exhibited positive effects on brain-derived neurotrophic factor (BDNF) levels. Moreover, this study establishes a clear positive association between short-term and working memory and neurotrophic biomarkers. In addition, the independent predictive value of change in insulin-like growth factor-1 (IGF-1) on improvement in short-term and working memory highlight the close relationship between neurotrophic markers and cognition. Consequently, our results advocate for exercise training interventions targeting neurotrophic biomarkers to enhance cognitive function among individuals with coronary artery disease.

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运动训练负荷变化对冠心病患者认知能力和神经营养生物标志物的影响。
目的:本研究比较了线性(LP)和非线性(NLP)训练周期对冠状动脉疾病(CAD)患者静息认知功能、神经营养生物标志物(脑源性神经营养因子[BDNF]、胰岛素样生长因子-1[IGF-1])和cathepsin-B的影响:44名冠心病患者在训练前后两次到我们的实验室接受测试,然后被盲法随机分配到NLP或LP进行36次训练。第1次检查包括血液样本和最大心肺运动测试,以获得最大摄氧量(V̇O2peak)。第2次检查包括认知功能评估:39名患者完成了研究(LP:20人,NLP:19人),两组患者在训练干预后认知能力均未发生变化。两组患者的 IGF-1 浓度均有所下降(时间效应:P0.05)。在汇总样本中发现,ΔV̇O2peak 与 ΔBDNF(R2=0.18,p=0.04)、ΔIGF-1 与 Δ短期/工作记忆(R2=0.17,p=0.01)之间存在关联,ΔIGF-1 和 ΔBDNF占 Δ短期/工作记忆变异的 10%。在LP组中,ΔV̇O2peak与ΔBDNF(R2=0.45,p=0.02)、ΔBDNF与Δ短期/工作记忆(R2=0.62,p=0.004)、ΔIGF-1与Δ短期/工作记忆(R2=0.31,p=0.01)、ΔIGF-1与Δ执行功能(R2=0.22,p=0.04)之间存在关联:这一发现凸显了监测BDNF和IGF-1浓度并将其作为改善CAD患者短期记忆和工作记忆的潜在生物标志物的重要性。
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来源期刊
CiteScore
6.00
自引率
9.10%
发文量
296
审稿时长
2-4 weeks
期刊介绍: The Journal of Applied Physiology publishes the highest quality original research and reviews that examine novel adaptive and integrative physiological mechanisms in humans and animals that advance the field. The journal encourages the submission of manuscripts that examine the acute and adaptive responses of various organs, tissues, cells and/or molecular pathways to environmental, physiological and/or pathophysiological stressors. As an applied physiology journal, topics of interest are not limited to a particular organ system. The journal, therefore, considers a wide array of integrative and translational research topics examining the mechanisms involved in disease processes and mitigation strategies, as well as the promotion of health and well-being throughout the lifespan. Priority is given to manuscripts that provide mechanistic insight deemed to exert an impact on the field.
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