F wave analysis based on the compound muscle action potential scan.

IF 2.8 3区医学 Q2 CLINICAL NEUROLOGY Muscle & Nerve Pub Date : 2024-09-01 Epub Date: 2024-07-04 DOI:10.1002/mus.28197

Xiaoyan Li, Maoqi Chen, Paul E Barkhaus, Sanjeev D Nandedkar, Brian Schmit, Ping Zhou

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Abstract

Introduction/aims: Conventional F wave analysis involves a relatively uniform physiological environment induced by supramaximal stimulations. The F wave characteristics in a dynamic physiological condition, however, are rarely investigated. This study aimed to improve understanding of F wave properties in the more dynamic process by introducing a novel method to analyze F waves based on the compound muscle action potential (CMAP) scan technique.

Methods: Twenty four healthy subjects participated in the study. The CMAP scan was applied to record muscle responses in the abductor pollicis brevis (APB) and abductor digiti minimi (ADM) muscles, respectively. F wave characteristics including mean F wave amplitude and latency (F-M latency), persistence and activating threshold were quantified.

Results: An average of 200 F waves per muscle were obtained from the CMAP scan recording. Weak to moderate correlations between F wave amplitude and stimulating intensity were observed in most of the APB (19 muscles; r = 0.33 ± 0.14, all p < .05) and ADM (23 muscles, r = 0.46 ± 0.16, all p < .05) muscles. Significantly longer mean F latency and lower activating F-threshold were found in the ADM muscles (F-M latency: APB: 25.43 ± 2.39 ms, ADM: 26.15 ± 2.32 ms, p < .05; F-threshold: APB: 7.68 ± 8.96% CMAP, ADM: 2.35 ± 2.42% CMAP, p < .05).

Discussion: This study introduces new features of F waves using the CMAP scan technique and identifies differences of F wave characteristics between the hand muscles. The CMAP scan based F waves analysis can be combined with the motor unit number estimation to assess functional alterations in motor neurons in neurological disorders.

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基于复合肌肉动作电位扫描的 F 波分析。

引言/目的：传统的 F 波分析涉及超大刺激所诱导的相对均匀的生理环境。然而，人们很少研究动态生理条件下的 F 波特性。本研究旨在通过引入一种基于复合肌肉动作电位（CMAP）扫描技术的新型 F 波分析方法，加深对更动态过程中 F 波特性的理解：方法：24 名健康受试者参与研究。方法：24 名健康受试者参加了这项研究。CMAP 扫描分别用于记录内收肌 (APB) 和外展肌 (ADM) 的肌肉反应。量化了 F 波特征，包括平均 F 波振幅和潜伏期（F-M 潜伏期）、持续性和激活阈值：从 CMAP 扫描记录中平均获得每块肌肉 200 个 F 波。在大多数 APB（19 块肌肉；r = 0.33 ± 0.14，均为 p 讨论）中观察到 F 波振幅与刺激强度之间存在弱到中等程度的相关性：本研究利用 CMAP 扫描技术介绍了 F 波的新特征，并确定了不同手部肌肉之间 F 波特征的差异。基于 CMAP 扫描的 F 波分析可与运动单位数量估计相结合，以评估神经系统疾病中运动神经元的功能性改变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Muscle & Nerve 医学-临床神经学

CiteScore

6.40

自引率

5.90%

发文量

287

审稿时长

3-6 weeks

期刊介绍： Muscle & Nerve is an international and interdisciplinary publication of original contributions, in both health and disease, concerning studies of the muscle, the neuromuscular junction, the peripheral motor, sensory and autonomic neurons, and the central nervous system where the behavior of the peripheral nervous system is clarified. Appearing monthly, Muscle & Nerve publishes clinical studies and clinically relevant research reports in the fields of anatomy, biochemistry, cell biology, electrophysiology and electrodiagnosis, epidemiology, genetics, immunology, pathology, pharmacology, physiology, toxicology, and virology. The Journal welcomes articles and reports on basic clinical electrophysiology and electrodiagnosis. We expedite some papers dealing with timely topics to keep up with the fast-moving pace of science, based on the referees'' recommendation.