Exploring the therapeutic potential of steroidal alkaloids in managing Alzheimer’s disease

IF 2.1 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Steroids Pub Date : 2024-07-02 DOI:10.1016/j.steroids.2024.109468

Pratima P. Pandey, Maushmi S. Kumar

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Abstract

Steroidal alkaloids are secondary metabolites that are often found in plants, fungi and sponges. These compounds are considered as a source of bioactive compounds for the treatment of chronic diseases, such as neurological disorder like Alzheimer’s disease (AD). Some examples of alkaloid derivatives currently used to treat AD symptoms include galantamine, huperzine A, and other alkaloids. AD is a multifactorial disease caused by multiple factors such as inflammation, oxidative stress, and protein aggregation. Based on the various important neuroprotective activities and different pharmacological effects of steroidal alkaloids with polypharmacological modulatory effects, they can lead to the development of new drugs for the treatment of AD. There are limited studies on the involvement of steroidal alkaloids in AD. Therefore, the mechanisms and neuroprotective abilities of these compounds are still poorly understood. The purpose of this review article is to provide an overview of the mechanism, toxicity and neuroprotective benefits of steroidal alkaloids and to discuss future possibilities to improve the application of steroidal alkaloids as anti-AD agents. The therapeutic value and limitations of the steroidal alkaloid are investigated to provide new perspectives for future clinical development studies.

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探索甾体生物碱治疗阿尔茨海默病的潜力。

甾体生物碱是次生代谢产物，通常存在于植物、真菌和海绵中。这些化合物被认为是治疗慢性疾病（如阿尔茨海默病（AD）等神经系统疾病）的生物活性化合物来源。目前用于治疗阿尔茨海默病症状的生物碱衍生物包括加兰他敏、石杉碱甲和其他生物碱。阿兹海默症是一种多因素疾病，由炎症、氧化应激和蛋白质聚集等多种因素引起。基于甾体生物碱具有多种重要的神经保护活性和不同的药理作用，具有多药理调节作用，可以开发出治疗AD的新药。关于甾体生物碱参与 AD 的研究还很有限。因此，人们对这些化合物的作用机制和神经保护能力仍知之甚少。这篇综述文章旨在概述甾体生物碱的机制、毒性和神经保护作用，并探讨未来改进甾体生物碱作为抗 AD 药物应用的可能性。通过研究甾体生物碱的治疗价值和局限性，为未来的临床开发研究提供新的视角。

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来源期刊

Steroids 医学-内分泌学与代谢

CiteScore

5.10

自引率

3.70%

发文量

120

审稿时长

73 days

期刊介绍： STEROIDS is an international research journal devoted to studies on all chemical and biological aspects of steroidal moieties. The journal focuses on both experimental and theoretical studies on the biology, chemistry, biosynthesis, metabolism, molecular biology, physiology and pharmacology of steroids and other molecules that target or regulate steroid receptors. Manuscripts presenting clinical research related to steroids, steroid drug development, comparative endocrinology of steroid hormones, investigations on the mechanism of steroid action and steroid chemistry are all appropriate for submission for peer review. STEROIDS publishes both original research and timely reviews. For details concerning the preparation of manuscripts see Instructions to Authors, which is published in each issue of the journal.