Effects of topical insulin on second-degree burn wound healing: brief report.

IF 1 4区医学 Q4 DERMATOLOGY Wound management & prevention Pub Date : 2024-06-01 DOI:10.25270/wmp.23023

Vagner Franco da Silveira, Juliany Lino Gomes Silva, Maria Helena Melo Lima, Mario Jose Abdalla Saad

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Abstract

Background: Burns are classified according to their mechanism of injury, depth, affected body area, affected region or part of the body, and extent of the lesions. Topical insulin modulates the healing process. However, studies evaluating the effects of topical insulin treatment on burns in human patients are lacking.

Purpose: The purpose of this study was to investigate the effects of topical insulin on healing time of second-degree burns.

Methods: In this nonrandomized clinical trial, patients with second-degree burns were allocated to a control group (CG) or an intervention group (IG) in which wounds were treated with 1% silver sulfadiazine and topical insulin, respectively.

Results: Healing time was significantly shorter in the IG relative to the CG (9.1 ± 1.9 days and 12.7 ± 3.3 days, respectively; P < .05). The estimated burn area was similar in both groups (CG 1.44 ± 1.0%; IG 1.42 ± 0.53%).

Conclusion: In this study, topical insulin reduced healing time in second-degree burns. Further investigation is warranted to support wider use in clinical practice.

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局部胰岛素对二度烧伤伤口愈合的影响：简要报告。

背景：烧伤根据其损伤机制、深度、受影响的身体部位、受影响的区域或身体的一部分以及病变的范围进行分类。局部胰岛素可调节愈合过程。目的：本研究旨在探讨外用胰岛素对二度烧伤愈合时间的影响：在这项非随机临床试验中，二度烧伤患者被分配到对照组（CG）或干预组（IG），分别使用1%磺胺嘧啶银和外用胰岛素治疗伤口：干预组的愈合时间明显短于对照组（分别为 9.1 ± 1.9 天和 12.7 ± 3.3 天；P < .05）。两组的估计烧伤面积相似（CG 1.44 ± 1.0%；IG 1.42 ± 0.53%）：结论：在这项研究中，局部胰岛素缩短了二度烧伤的愈合时间。结论：在这项研究中，外用胰岛素缩短了二度烧伤的愈合时间，需要进一步研究，以支持在临床实践中广泛使用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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