Coenzyme Q₁₀ supplementation affects cellular ionic balance: relevance to aging.

IF 1.8 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences Pub Date : 2024-07-05 DOI:10.1515/znc-2024-0129

Parisha Srivastava, Sukanya Bhoumik, Arun K Yadawa, Rashmi Kesherwani, Syed Ibrahim Rizvi

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Abstract

Aging results into disruptive physiological functioning and cellular processes that affect the composition and structure of the plasma membrane. The plasma membrane is the major regulator of ionic homeostasis that regulates the functioning of membrane transporters and exchangers. Coenzyme Q₁₀ is a lipid-soluble antioxidant molecule that declines during aging and age-associated diseases. The present study aims to explore the role of Coenzyme Q₁₀ supplementation to rats during aging on membrane transporters and redox biomarkers. The study was conducted on young and old male Wistar rats supplemented with 20 mg/kg b.w. of Coenzyme Q₁₀ per day. After a period of 28 days, rats were sacrificed and erythrocyte membrane was isolated. The result exhibits significant decline in biomarkers of oxidative stress in old control rats when compared with young control. The effect of Coenzyme Q₁₀ supplementation was more pronounced in old rats. The functioning of membrane transporters and Na⁺/H⁺ exchanger showed potential return to normal levels in the Coenzyme Q₁₀ treated rats. Overall, the results demonstrate that Coenzyme Q₁₀ plays an important role in maintaining redox balance in cells which interconnects with membrane integrity. Thus, Coenzyme Q₁₀ supplementation may play an important role in protecting age related alterations in erythrocyte membrane physiology.

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辅酶 Q10 补充剂影响细胞离子平衡：与衰老有关。

衰老会破坏生理功能和细胞过程，从而影响质膜的组成和结构。质膜是离子平衡的主要调节器，可调节膜转运体和交换体的功能。辅酶 Q10 是一种脂溶性抗氧化剂分子，在衰老和与年龄有关的疾病中会减少。本研究旨在探讨大鼠在衰老过程中补充辅酶Q10对膜转运体和氧化还原生物标志物的作用。研究对象是年轻和年老的雄性Wistar大鼠，每天补充20毫克/千克体重的辅酶Q10。28天后，大鼠被处死并分离红细胞膜。结果显示，与年轻对照组相比，老年对照组大鼠的氧化应激生物标志物明显下降。补充辅酶 Q10 对老年大鼠的影响更为明显。经辅酶Q10处理的大鼠，膜转运体和Na+/H+交换器的功能有可能恢复到正常水平。总之，研究结果表明，辅酶Q10在维持细胞氧化还原平衡方面发挥着重要作用，而细胞氧化还原平衡与细胞膜的完整性息息相关。因此，补充辅酶Q10可在保护与年龄有关的红细胞膜生理变化方面发挥重要作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences 生物-生化与分子生物学

CiteScore

4.10

自引率

5.00%

发文量

期刊介绍： A Journal of Biosciences: Zeitschrift für Naturforschung C (ZNC) is an international scientific journal and a community resource for the emerging field of natural and natural-like products. The journal publishes original research on the isolation (including structure elucidation), bio-chemical synthesis and bioactivities of natural products, their biochemistry, pharmacology, biotechnology, and their biological activity and innovative developed computational methods for predicting the structure and/or function of natural products. A Journal of Biosciences: Zeitschrift für Naturforschung C (ZNC) welcomes research papers in fields on the chemistry-biology boundary which address scientific ideas and approaches to generate and understand natural compounds on a molecular level and/or use them to stimulate and manipulate biological processes.