TINNITUS. A Non-invasive Neuromodulatory Perspective

IF 2 4区医学 Q1 Medicine Current Treatment Options in Neurology Pub Date : 2024-06-18 DOI:10.1007/s11940-024-00802-w

Simone Rossi, Marco Mandalà

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Abstract

Purpose of the Review

Chronic tinnitus affects millions of people worldwide, but it remains an unmet clinical problem, particularly from a therapeutic perspective.

Recent Findings

Neuroimaging and neurophysiological investigations have consistently unveiled that tinnitus can be considered as a form of maladaptive plasticity taking place not only in primary and associative auditory areas but also involving large-scale brain networks. Based on these premises, treatment strategies that aim to manipulate in a controllable way plastic capabilities of the brain are being under investigation as emerging treatments.

Summary

here, we review the rationale for using so called Non-Invasive Brain stimulation (NiBS) techniques, such as navigated repetitive transcranial magnetic stimulation (rTMS) and other forms of transcranial electrical stimulation (tES) or peripheral stimulations, to alleviate tinnitus. We also provide an overview of available clinical results of these various non-invasive neuromodulatory approaches, trying to identify how to translate their unquestionable therapeutic potential into real-life contexts, beyond the lab boundaries.

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TINNITUS。非侵入性神经调节视角

最近的研究结果神经影像学和神经生理学研究不断揭示，耳鸣可被视为一种适应不良的可塑性，不仅发生在初级和联想听觉区域，还涉及大规模的大脑网络。在此，我们回顾了使用所谓的非侵入性脑部刺激（NiBS）技术（如导航式重复经颅磁刺激（rTMS）和其他形式的经颅电刺激（tES）或外周刺激）来缓解耳鸣的原理。我们还概述了这些非侵入性神经调节方法的现有临床结果，试图确定如何将其毋庸置疑的治疗潜力转化为超越实验室界限的现实生活环境。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Treatment Options in Neurology CLINICAL NEUROLOGY-

CiteScore

4.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： This journal aims to review the most important, recently published treatment option advances in the field of neurology. By presenting clear, insightful, balanced contributions by international experts, the journal intends to facilitate worldwide approaches to the treatment of neurologic conditions. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as epilepsy, headache, neurologic ophthalmology and otology, neuromuscular disorders, psychiatric manifestations of neurologic disease, and sleep disorders. Section Editors select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. We also provide commentaries from well-known neurologists, and an international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research.