Cognitive impairment associated with individual and joint exposure to PM2.5 constituents in a Chinese national cohort

IF 6.1 2区 环境科学与生态学 Q2 ENGINEERING, ENVIRONMENTAL Frontiers of Environmental Science & Engineering Pub Date : 2024-06-25 DOI:10.1007/s11783-024-1869-3
Boning Deng, Yachen Li, Lifeng Zhu, Yuwei Zhou, Aonan Sun, Jingjing Zhang, Yixiang Wang, Yuxi Tan, Jiajun Shen, Yalin Zhang, Zan Ding, Yunquan Zhang
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Abstract

Nationwide longitudinal evidence linking cognitive decline with exposure to fine particulate matter (PM2.5) constituents remains scarce in China. By constructing a dynamic cohort based on the China Health and Retirement Longitudinal Study, we aimed to assess individual and joint associations of PM2.5 constituents with cognitive function among middle-aged and older adults in China. Linear mixed-effects models incorporated with quantile-based g-computation were applied to investigate individual and joint associations of long-term exposures to PM2.5 constituents with cognitive function. Among 13,507 respondents, we evaluated 38,950 follow-up records of cognitive function tests. Declines in global cognitive score associated with an interquartile range (IQR) increase in exposure were −1.477 (95% CI: −1.722, −1.232) for nitrate, followed by −1.331 (−1.529, −1.133) for ammonium, −1.033 (−1.184, −0.883) for sulfate, −0.988 (−1.144, −0.832) for organic matter and −0.822 (−0.946, −0.699) for black carbon. An IQR-equivalent increase in joint exposure to these PM2.5 constituents was associated with a decline of −1.353 (−1.659, −1.048) in global cognitive score. Female, younger, and well-educated individuals were at greater vulnerability to cognitive impairment related to individual and joint exposure to PM2.5 constituents. This study suggested that later-life exposures to PM2.5 constituents were associated with cognitive decline in middle-aged and older adults in China.

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中国国家队列中与个人和共同暴露于 PM2.5 成分相关的认知障碍
在中国,将认知功能下降与细颗粒物(PM2.5)暴露联系起来的全国性纵向证据仍然很少。通过在中国健康与退休纵向研究的基础上构建动态队列,我们旨在评估中国中老年人PM2.5成分与认知功能的个体和联合关联。我们采用了线性混合效应模型和基于量纲的 g 计算方法来研究长期暴露于 PM2.5 成分与认知功能之间的个体和联合关系。在 13,507 名受访者中,我们评估了 38,950 份认知功能测试的随访记录。与暴露量四分位数间距(IQR)增加相关的全球认知分数下降情况是:硝酸盐为-1.477(95% CI:-1.722,-1.232),其次是铵:-1.331(-1.529,-1.133),硫酸盐:-1.033(-1.184,-0.883),有机物:-0.988(-1.144,-0.832),黑碳:-0.822(-0.946,-0.699)。PM2.5中这些成分的IQR值每增加1,全球认知分数就会下降-1.353(-1.659,-1.048)。女性、年轻人和受过良好教育的人更容易受到与个人和共同暴露于PM2.5成分有关的认知障碍的影响。这项研究表明,中国中老年人在晚年暴露于PM2.5成分与认知能力下降有关。
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来源期刊
Frontiers of Environmental Science & Engineering
Frontiers of Environmental Science & Engineering ENGINEERING, ENVIRONMENTAL-ENVIRONMENTAL SCIENCES
CiteScore
10.90
自引率
12.50%
发文量
988
审稿时长
6.1 months
期刊介绍: Frontiers of Environmental Science & Engineering (FESE) is an international journal for researchers interested in a wide range of environmental disciplines. The journal''s aim is to advance and disseminate knowledge in all main branches of environmental science & engineering. The journal emphasizes papers in developing fields, as well as papers showing the interaction between environmental disciplines and other disciplines. FESE is a bi-monthly journal. Its peer-reviewed contents consist of a broad blend of reviews, research papers, policy analyses, short communications, and opinions. Nonscheduled “special issue” and "hot topic", including a review article followed by a couple of related research articles, are organized to publish novel contributions and breaking results on all aspects of environmental field.
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