Kazuki Hori, Shunsuke Onuma, Yuta Nakazato, Tomoya Mashiko, Akihiko Kasamatsu, Akinobu Matsuzawa, Shogo Kamo, Kazuyuki Sugita
{"title":"Total syntheses of fungal isoindolinones corallocins B and C","authors":"Kazuki Hori, Shunsuke Onuma, Yuta Nakazato, Tomoya Mashiko, Akihiko Kasamatsu, Akinobu Matsuzawa, Shogo Kamo, Kazuyuki Sugita","doi":"10.1002/jhet.4853","DOIUrl":null,"url":null,"abstract":"<p>The first total syntheses of corallocins B and C are described herein. The Suzuki–Miyaura coupling was key to completion. Because these two natural products have been reported to induce neurotrophin expression in human astrocytes, they are expected to serve as new drug leads for neurodegenerative diseases.</p>","PeriodicalId":194,"journal":{"name":"Journal of Heterocyclic Chemistry","volume":"61 9","pages":"1399-1404"},"PeriodicalIF":2.0000,"publicationDate":"2024-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Heterocyclic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jhet.4853","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
The first total syntheses of corallocins B and C are described herein. The Suzuki–Miyaura coupling was key to completion. Because these two natural products have been reported to induce neurotrophin expression in human astrocytes, they are expected to serve as new drug leads for neurodegenerative diseases.
期刊介绍：
The Journal of Heterocyclic Chemistry is interested in publishing research on all aspects of heterocyclic chemistry, especially development and application of efficient synthetic methodologies and strategies for the synthesis of various heterocyclic compounds. In addition, Journal of Heterocyclic Chemistry promotes research in other areas that contribute to heterocyclic synthesis/application, such as synthesis design, reaction techniques, flow chemistry and continuous processing, multiphase catalysis, green chemistry, catalyst immobilization and recycling.
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