{"title":"Photothermal and Photodynamic Synergistic Effect of the MXene/SnS2 Heterojunction Endows the Poly(l-lactic acid) Scaffold with Antibacterial Activity","authors":"Cijun Shuai, Xingming Long, Binxin Sun, Tiantian He, Xiong Shuai, Guoyong Wang* and Shuping Peng*, ","doi":"10.1021/acsapm.4c01336","DOIUrl":null,"url":null,"abstract":"<p >Bacterial infection is a severe challenge faced by artificial bone transplantation, which might cause delayed bone healing or even transplant failure. Photodynamic therapy (PDT) has garnered widespread attention as a treatment for infections due to its noninvasiveness, few side effects, and high spatiotemporal selectivity. Nevertheless, owing to the bacterial membrane obstacle, it is difficult for exogenous reactive oxygen species (ROS) to penetrate into bacteria, which leads to an unsatisfactory antibacterial effect. Herein, a heterojunction of Ti<sub>2</sub>C<sub>3</sub> nanosheets/tin disulfide (MXene/SnS<sub>2</sub>) is designed, which integrates photothermal and photodynamic properties. Then, MXene/SnS<sub>2</sub> was incorporated into a poly-<span>l</span>-lactic acid powder (PLLA) matrix to fabricate an artificial bone scaffold with selective laser sintering (SLS) technology. Under near-infrared laser irradiation, SnS<sub>2</sub> can strengthen the near-infrared light absorption of MXene to generate local hyperthermia, thus enhancing bacterial membrane permeability. Meanwhile, MXene/SnS<sub>2</sub> enhances charge transfer and inhibits electron–hole pair separation, thereby generating more ROS that can penetrate the bacterial interior. The results indicated that this antibacterial strategy has effective antibacterial activity, and the antibacterial rate reached over 90%. Overall, this research presents an attractive antibacterial strategy for implant-related infection.</p>","PeriodicalId":7,"journal":{"name":"ACS Applied Polymer Materials","volume":null,"pages":null},"PeriodicalIF":4.4000,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Polymer Materials","FirstCategoryId":"92","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acsapm.4c01336","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Bacterial infection is a severe challenge faced by artificial bone transplantation, which might cause delayed bone healing or even transplant failure. Photodynamic therapy (PDT) has garnered widespread attention as a treatment for infections due to its noninvasiveness, few side effects, and high spatiotemporal selectivity. Nevertheless, owing to the bacterial membrane obstacle, it is difficult for exogenous reactive oxygen species (ROS) to penetrate into bacteria, which leads to an unsatisfactory antibacterial effect. Herein, a heterojunction of Ti2C3 nanosheets/tin disulfide (MXene/SnS2) is designed, which integrates photothermal and photodynamic properties. Then, MXene/SnS2 was incorporated into a poly-l-lactic acid powder (PLLA) matrix to fabricate an artificial bone scaffold with selective laser sintering (SLS) technology. Under near-infrared laser irradiation, SnS2 can strengthen the near-infrared light absorption of MXene to generate local hyperthermia, thus enhancing bacterial membrane permeability. Meanwhile, MXene/SnS2 enhances charge transfer and inhibits electron–hole pair separation, thereby generating more ROS that can penetrate the bacterial interior. The results indicated that this antibacterial strategy has effective antibacterial activity, and the antibacterial rate reached over 90%. Overall, this research presents an attractive antibacterial strategy for implant-related infection.
期刊介绍:
ACS Applied Polymer Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics, and biology relevant to applications of polymers.
The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates fundamental knowledge in the areas of materials, engineering, physics, bioscience, polymer science and chemistry into important polymer applications. The journal is specifically interested in work that addresses relationships among structure, processing, morphology, chemistry, properties, and function as well as work that provide insights into mechanisms critical to the performance of the polymer for applications.