K Tamura, H Mizuno, K Okada, H Katoh, S Hitomi, T Teramatsu, Y Shimizu, T Hino
{"title":"Experimental application of polyvinyl alcohol-silica for small artificial vessels.","authors":"K Tamura, H Mizuno, K Okada, H Katoh, S Hitomi, T Teramatsu, Y Shimizu, T Hino","doi":"10.3109/10731198509118847","DOIUrl":null,"url":null,"abstract":"<p><p>Polyvinyl alcohol-silica (PVA-SiO2) composite and heparinized PVA-SiO2 were examined in vitro and in vivo as materials to coat artificial vessels to be used for the replacement of small arteries. PVA-SiO2 was observed to prolong coagulation time and on heparinized PVA-SiO2 surfaces no blood coagulation was noticed after a period of two days using the Lee-White and plasma recalcification methods. After placing non-coated and coated surfaces in contact with blood components in vitro and in vivo, the degree of blood component adhesion was greater in non-coated woven Dacron than in PVA-SiO2 coated Dacron. The degree of adhesion was even less in heparinized PVA-SiO2 coated Dacron. Furthermore, artificial vessels made of these 3 types of materials were used to replace parts of the canine abdominal aorta and were removed one and a half years later. Patency rates were as follows: non-coated 2/7, PVA-SiO2-coated 4/7, heparinized PVA-SiO2-coated 8/12. The inner surfaces of these prostheses were observed with light microscopy and scanning electron microscopy. Intima formation was thinner on the PVA-SiO2 composite surfaces than on the control surfaces. Heparin acted as a local anticoagulant and PVA-SiO2 limited intima formation. This report showed that PVA-SiO2 composite coated surfaces can be effective for small artery replacement due to good tissue affinity and anticoagulability.</p>","PeriodicalId":75597,"journal":{"name":"Biomaterials, medical devices, and artificial organs","volume":"13 3-4","pages":"133-52"},"PeriodicalIF":0.0000,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10731198509118847","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomaterials, medical devices, and artificial organs","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3109/10731198509118847","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3
Abstract
Polyvinyl alcohol-silica (PVA-SiO2) composite and heparinized PVA-SiO2 were examined in vitro and in vivo as materials to coat artificial vessels to be used for the replacement of small arteries. PVA-SiO2 was observed to prolong coagulation time and on heparinized PVA-SiO2 surfaces no blood coagulation was noticed after a period of two days using the Lee-White and plasma recalcification methods. After placing non-coated and coated surfaces in contact with blood components in vitro and in vivo, the degree of blood component adhesion was greater in non-coated woven Dacron than in PVA-SiO2 coated Dacron. The degree of adhesion was even less in heparinized PVA-SiO2 coated Dacron. Furthermore, artificial vessels made of these 3 types of materials were used to replace parts of the canine abdominal aorta and were removed one and a half years later. Patency rates were as follows: non-coated 2/7, PVA-SiO2-coated 4/7, heparinized PVA-SiO2-coated 8/12. The inner surfaces of these prostheses were observed with light microscopy and scanning electron microscopy. Intima formation was thinner on the PVA-SiO2 composite surfaces than on the control surfaces. Heparin acted as a local anticoagulant and PVA-SiO2 limited intima formation. This report showed that PVA-SiO2 composite coated surfaces can be effective for small artery replacement due to good tissue affinity and anticoagulability.