Paclitaxel-Loaded PLGA/Au Nanocylinders for the Photothermal-Chemotherapy Treatment of Cancer

IF 5.3 2区材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY ACS Applied Nano Materials Pub Date : 2024-06-25 DOI:10.1021/acsanm.3c05457

Xiang Zhang, Yurui Xu, Wanyao Chen, Laiyou Wang, Xinghai Ning, Haixiong Ge

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Abstract

UV-nanoimprint lithography (UV-NIL) has been proved to be an efficient method for preparing nanodrug delivery systems. Herein, we used UV-NIL associated with the glancing angle deposition (GLAD) process of electron beam evaporation to prepare Au-coated PLGA nanocylinders loaded with PTX (PTX-PLGA-Au NCs) to enhance anticancer efficacy by the cooperative treatment of photothermal-chemotherapy. PTX-PLGA-Au NCs with different length-to-diameter ratios can be prepared by controlling the concentration of PLGA and regulating the angle of GLAD. Upon 808 nm near-infrared (NIR) irradiation, PTX-PLGA-Au NCs exhibit a stable and repeatable photothermal effect. Besides, hyperthermia generated by the Au layer on the surface of PTX-PLGA-Au NCs under laser irradiation promoted the rapid release of PTX. The in vitro studies demonstrated that PTX-PLGA-Au NCs can achieve the synergistic effect of photothermal-chemotherapy, leading to increased cell cytotoxicity. Therefore, UV-NIL combined with the GLAD process produced a promising nanofabrication method for efficiently developing a multifunctional nanoplatform for cancer treatment.

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用于癌症光热化疗的紫杉醇负载聚乳酸乙烯雌酚/金纳米圆柱体

紫外纳米压印光刻（UV-NIL）已被证明是制备纳米药物递送系统的一种有效方法。在此，我们利用紫外-纳米压印光刻技术结合电子束蒸发的闪烁角沉积（GLAD）工艺制备了负载PTX的金包覆PLGA纳米圆柱（PTX-PLGA-Au NCs），通过光热化疗的协同治疗提高抗癌疗效。通过控制 PLGA 的浓度和调节 GLAD 的角度，可以制备出不同长径比的 PTX-PLGA-Au NCs。在 808 纳米近红外（NIR）照射下，PTX-PLGA-Au NCs 表现出稳定、可重复的光热效应。此外，在激光照射下，PTX-PLGA-Au NCs 表面的金层产生的高热促进了 PTX 的快速释放。体外研究表明，PTX-PLGA-Au NCs 可实现光热化疗的协同效应，从而增强细胞毒性。因此，UV-NIL 与 GLAD 工艺相结合是一种很有前景的纳米制造方法，可用于高效开发治疗癌症的多功能纳米平台。

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来源期刊

ACS Applied Nano Materials Multiple-

CiteScore

8.30

自引率

3.40%

发文量

1601

期刊介绍： ACS Applied Nano Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics and biology relevant to applications of nanomaterials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important applications of nanomaterials.