G. G. Kutlugildina, Yu. S. Zimin, A. R. Gimadieva, E. F. Repina, E. R. Kudoyarov
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引用次数: 0
Abstract
5-Hydroxy-6-methyluracil (5-OH-6-MU) was shown to form a 1:1 complex with N-acetylcysteine (N-AC), i.e., the compounds interacted in an equimolar ratio. The temperature dependence of the stability constant was studied in the range 291-316 K. The thermodynamic parameters of the complexation process were determined. Aprocedure for the synthesis of the 5-OH-6-MU…N-AC complex was developed based on the results. The toxicity and antihypoxic activity of the complex were subsequently studied. The synthesized compound at a dose of 500 mg/kg in mice had low toxicity and antihypoxic activity significantly superior to those of the reference drugs (5-OH-6-MU and N-AC).
期刊介绍：
Pharmaceutical Chemistry Journal is a monthly publication devoted to scientific and technical research on the creation of new drugs and the improvement of manufacturing technology of drugs and intermediates. International contributors cover the entire spectrum of new drug research, including:
methods of synthesis;
results of pharmacological, toxicological, and biochemical studies;
investigation of structure - activity relationships in prediction of new compounds;
methods and technical facilities used; and
problems associated with the development of ecologically safe and economically feasible methods of industrial production.
In addition, analytical reviews of the international literature in the field provide coverage of the most recent developments around the world.
Pharmaceutical Chemistry Journal is a translation of the Russian journal Khimiko-Farmatsevticheskii Zhurnal. The Russian Volume Year is published in English from April.
All articles are peer-reviewed.
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