Modulatory Effect of Blood LDL Cholesterol on the Association between Cerebral Aβ and Tau Deposition in Older Adults

S. M. Han, M. S. Byun, D. Yi, J. H. Jung, N. Kong, Y. Y. Chang, M. Keum, G. J. Jung, J.-Y. Lee, Y.-S. Lee, Y. K. Kim, K. M. Kang, C.-H. Sohn, Dong Young Lee
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Abstract

Background

This study investigates the synergistic relationship between blood low-density lipoprotein cholesterol (LDL-C) and cerebral beta-amyloid (Aβ) in relation to tau deposition, a key factor in the pathology of Alzheimer’s disease (AD), in older adults across a diverse cognitive spectrum.

Objectives

To examine whether higher levels of LDL-C in the blood moderate the association of cerebral Aβ with tau deposition in older adults, including those with normal cognition, mild cognitive impairment, and Alzheimer’s disease dementia.

Design

Cross-sectional design. Setting: The study was conducted as a part of a prospective cohort study. All assessments were done at the Seoul National University Hospital, Seoul, South Korea. Participants: A total of 136 older adults (aged 60–85 years) with normal cognition, mild cognitive impairment or Alzheimer’s disease (AD) dementia were included.

Measurements

Serum lipid measurements, [11C] Pittsburgh Compound B-positron emission tomography (PET), [18F] AV-1451 PET, and magnetic resonance imaging were performed on all participants.

Results

There was a significant Aβ × LDL-C interaction effect on tau deposition indicating a synergistic moderation effect of LDL-C on the relationship between Aβ and tau deposition. Subsequent subgroup analysis showed that the positive association between Aβ and tau deposition was stronger in higher LDL-C group than in lower LDL-C group. In contrast, other lipids, such as total cholesterol, high-density lipoprotein cholesterol, and triglycerides, did not show a similar moderation effect on the relationship between Aβ deposition and tau deposition.

Conclusion

Our findings suggest that blood LDL-C synergistically enhances the influence of Aβ deposition on tau pathology, emphasizing the need for greater attention to the role of LDL-C in AD progression.

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血液中低密度脂蛋白胆固醇对老年人大脑 Aβ 和 Tau 沉积之间关系的调节作用
背景本研究探讨了血液中低密度脂蛋白胆固醇(LDL-C)和脑β-淀粉样蛋白(Aβ)之间的协同关系,这种协同关系与不同认知范围的老年人中阿尔茨海默病(AD)病理学的关键因素--tau沉积有关。目的 研究血液中较高水平的低密度脂蛋白胆固醇是否会缓和老年人(包括认知正常、轻度认知障碍和阿尔茨海默病痴呆症患者)脑Aβ与tau沉积的关系。地点该研究是前瞻性队列研究的一部分。所有评估均在韩国首尔的首尔国立大学医院进行。参加者:136 名老年人(其中包括一名老年痴呆症患者):测量对所有参与者进行了血清脂质测量、[11C] 匹兹堡化合物 B 正电子发射断层扫描(PET)、[18F] AV-1451 正电子发射断层扫描和磁共振成像。结果Aβ×LDL-C对tau沉积有明显的交互作用,表明LDL-C对Aβ和tau沉积之间的关系有协同调节作用。随后的亚组分析显示,Aβ与tau沉积之间的正相关在高LDL-C组比低LDL-C组更强。结论我们的研究结果表明,血液中的低密度脂蛋白胆固醇会协同增强Aβ沉积对tau病理学的影响,这强调了需要更加关注低密度脂蛋白胆固醇在AD进展中的作用。
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The Journal of Prevention of Alzheimer's Disease
The Journal of Prevention of Alzheimer's Disease Medicine-Psychiatry and Mental Health
CiteScore
9.20
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0.00%
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期刊介绍: The JPAD Journal of Prevention of Alzheimer’Disease will publish reviews, original research articles and short reports to improve our knowledge in the field of Alzheimer prevention including: neurosciences, biomarkers, imaging, epidemiology, public health, physical cognitive exercise, nutrition, risk and protective factors, drug development, trials design, and heath economic outcomes.JPAD will publish also the meeting abstracts from Clinical Trial on Alzheimer Disease (CTAD) and will be distributed both in paper and online version worldwide.We hope that JPAD with your contribution will play a role in the development of Alzheimer prevention.
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