Synthesis of Methoxy Analogues of Coenzyme Q10 Metabolites from Parsley Seed Extracts via Baeyer–Villiger Rearrangement of Carbonyl-Substituted Polyalkoxybenzenes
Dmitry V. Demchuk, Olga I. Adaeva, Dmitry V. Tsyganov, Darina I. Nasyrova, Roman A. Dolotov, Еgor А. Muravsky, Alexander E. Varakutin, Alexander V. Samet, Victor V. Semenov
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引用次数: 0
Abstract
Based on the parsley seed main component, apiol, efficient approach to polymethoxyquinone C3- and C4-acids was developed. The key step of this approach is Baeyer–Villiger rearrangement of carbonyl-substituted polyalkoxybenzenes derived from parsley seed extracts. These acids are the MeO-analogues of natural antioxidants – metabolites of ubiquinone and idebenone. Due to antioxidant properties, they are the potential therapeutic candidates for the treatment of mitochondrial dysfunction.
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