Min-Hyeok Kim, Yugyeong Lee, Gwang Myeong Seo, Sungsu Park
{"title":"Advancements in Kidney-on-Chip: Antibiotic-Induced Kidney Injury and Future Directions","authors":"Min-Hyeok Kim, Yugyeong Lee, Gwang Myeong Seo, Sungsu Park","doi":"10.1007/s13206-024-00160-4","DOIUrl":null,"url":null,"abstract":"<p>This review paper aims to critically assess the advancements, challenges, and future prospects of kidney-on-chip (KOC) technology in studying antibiotic-induced kidney injury. Despite significant progress, challenges such as limited throughput and the need for more accurate physiological replication persist. By analyzing current literature and technological developments, this review identifies key issues and outlines future directions for KOC research. Through an exploration of sensor integration, high-throughput screening capabilities, and automation, this review seeks to address these challenges and propel KOC toward more efficient and predictive drug-testing methodologies.</p>","PeriodicalId":8768,"journal":{"name":"BioChip Journal","volume":"9 1","pages":""},"PeriodicalIF":5.5000,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BioChip Journal","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1007/s13206-024-00160-4","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}
引用次数: 0
Abstract
This review paper aims to critically assess the advancements, challenges, and future prospects of kidney-on-chip (KOC) technology in studying antibiotic-induced kidney injury. Despite significant progress, challenges such as limited throughput and the need for more accurate physiological replication persist. By analyzing current literature and technological developments, this review identifies key issues and outlines future directions for KOC research. Through an exploration of sensor integration, high-throughput screening capabilities, and automation, this review seeks to address these challenges and propel KOC toward more efficient and predictive drug-testing methodologies.
期刊介绍:
BioChip Journal publishes original research and reviews in all areas of the biochip technology in the following disciplines, including protein chip, DNA chip, cell chip, lab-on-a-chip, bio-MEMS, biosensor, micro/nano mechanics, microfluidics, high-throughput screening technology, medical science, genomics, proteomics, bioinformatics, medical diagnostics, environmental monitoring and micro/nanotechnology. The Journal is committed to rapid peer review to ensure the publication of highest quality original research and timely news and review articles.