A Novel MRI-Based Paravertebral Muscle Quality (PVMQ) Score for Evaluating Muscle Quality and Bone Quality: A Comparative Study with the VBQ Score

IF 3.6 3区医学 Clinical Interventions in Aging Pub Date : 2024-07-02 DOI:10.2147/cia.s464187

Song Wang, Xiang Zhang, Bo Qu, Kunhai Yang, Yongrong Hu, Hao Liu, Juntao Hong, Hao Niu, Hongsheng Yang

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Abstract

Purpose: This study aims to develop a novel MRI-based paravertebral muscle quality (PVMQ) score for assessing muscle quality and to investigate its correlation with the degree of fat infiltration (DFF) and the vertebral bone quality (VBQ) score of paravertebral muscles. Additionally, the study compares the effectiveness of the PVMQ score and the VBQ score in assessing muscle quality and bone quality.
Methods: PVMQ scores were derived from the ratio of paravertebral muscle signal intensity (SI) to L3 cerebrospinal fluid SI on T2-weighted MRI. Image J software assessed paravertebral muscle cross-sectional area (CSA) and DFF. Spearman rank correlation analyses explored associations between PVMQ, VBQ scores, DFF, and T-scores in both genders. Receiver operating characteristic (ROC) curves compared PVMQ and VBQ scores’ effectiveness in distinguishing osteopenia/osteoporosis and high paraspinal muscle DFF.
Results: In this study of 144 patients (94 females), PVMQ scores were significantly higher in osteoporosis and osteopenia groups compared to normals, with variations observed between genders (P < 0.05). PVMQ showed stronger positive correlation with VBQ scores and DFF in females than males (0.584 vs 0.445, 0.579 vs 0.528; P < 0.01). ROC analysis favored PVMQ over VBQ for low muscle mass in both genders (AUC = 0.767 vs 0.718, 0.793 vs 0.718). VBQ was better for bone mass in males (0.737/0.865 vs 0.691/0.858), whereas PVMQ excelled for females (0.808/0.764 vs 0.721/0.718).
Conclusion: The novel PVMQ score provides a reliable assessment of paravertebral muscle quality and shows a strong correlation with VBQ scores and DFF, particularly in females. It outperforms VBQ scores in evaluating muscle mass and offers valuable insights for assessing bone mass in females. These findings underscore the potential of the PVMQ score as a dual-purpose tool for evaluating both muscle and bone health, informing future research and clinical practice.

Keywords: muscle quality, osteoporosis, magnetic resonance imaging, dual-energy X-ray absorptiometry, vertebral bone quality score, osteosarcopenia

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基于 MRI 的椎旁肌肉质量 (PVMQ) 评估肌肉质量和骨骼质量的新评分：与 VBQ 评分的比较研究

目的：本研究旨在开发一种基于磁共振成像的新型椎旁肌肉质量（PVMQ）评分方法，用于评估肌肉质量，并研究其与椎旁肌肉脂肪浸润程度（DFF）和椎骨质量（VBQ）评分的相关性。此外，该研究还比较了 PVMQ 评分和 VBQ 评分在评估肌肉质量和骨骼质量方面的有效性：PVMQ评分是根据T2加权磁共振成像上椎旁肌肉信号强度（SI）与L3脑脊液SI的比值得出的。Image J软件评估了椎旁肌肉横截面积（CSA）和DFF。斯皮尔曼秩相关分析探讨了男女两性的 PVMQ、VBQ 分数、DFF 和 T 分数之间的关联。接收器操作特征曲线（ROC）比较了 PVMQ 和 VBQ 分数在区分骨质疏松症/骨质疏松症和脊柱旁肌肉 DFF 高的有效性：在这项对 144 名患者（94 名女性）进行的研究中，与正常人相比，骨质疏松症和骨质疏松症组的 PVMQ 分数明显较高，性别之间存在差异（P < 0.05）。女性的 PVMQ 与 VBQ 评分和 DFF 呈更强的正相关（0.584 vs 0.445，0.579 vs 0.528；P < 0.01）。ROC分析显示，对于低肌肉质量，PVMQ比VBQ更适用于男性和女性（AUC = 0.767 vs 0.718, 0.793 vs 0.718）。VBQ 对男性骨量的影响更好（0.737/0.865 vs 0.691/0.858），而 PVMQ 对女性的影响更好（0.808/0.764 vs 0.721/0.718）：结论：新的 PVMQ 评分能可靠地评估椎旁肌肉质量，并与 VBQ 评分和 DFF 显示出很强的相关性，尤其是对女性而言。它在评估肌肉质量方面优于 VBQ 评分，并为评估女性骨量提供了有价值的见解。这些发现强调了 PVMQ 评分作为评估肌肉和骨骼健康的两用工具的潜力，为未来的研究和临床实践提供了参考。关键词：肌肉质量；骨质疏松症；磁共振成像；双能 X 射线吸收测量法；椎骨质量评分；骨质疏松症

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来源期刊

Clinical Interventions in Aging GERIATRICS & GERONTOLOGY-

CiteScore

6.20

自引率

2.80%

发文量

193

期刊介绍： Clinical Interventions in Aging, is an online, peer reviewed, open access journal focusing on concise rapid reporting of original research and reviews in aging. Special attention will be given to papers reporting on actual or potential clinical applications leading to improved prevention or treatment of disease or a greater understanding of pathological processes that result from maladaptive changes in the body associated with aging. This journal is directed at a wide array of scientists, engineers, pharmacists, pharmacologists and clinical specialists wishing to maintain an up to date knowledge of this exciting and emerging field.