Modifiable Risk Factors for Breast Cancer Mortality in Türkiye from 1990 to 2019: A Temporal Analysis of Global Burden of Disease Data.

IF 1.9 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Balkan Medical Journal Pub Date : 2024-07-05 DOI:10.4274/balkanmedj.galenos.2024.2024-4-91
Ali Cem Yekdeş, Didem Han Yekdeş, Ülfiye Çelikkalp, Galip Ekuklu
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Abstract

Background: Breast cancer is the leading cause of cancer-related mortality in women in Türkiye.

Aims: Explore the trends in female breast cancer mortality rates and the associated modifiable factors in Türkiye between 1990 and 2019.

Study design: Epidemiological descriptive analysis.

Methods: The database of the Global Burden of Disease study was used to obtain data regarding breast cancer-related mortality and modifiable (behavioral and metabolic) risk factors among women in Türkiye from 1990 to 2019. The average annual percentage change (AAPC) for female breast cancer mortality rates was computed using the Joinpoint regression method.

Results: From 1990 to 2009, the breast cancer mortality rates in Türkiye tended to increase [from 12.26/105 in 1990 to 12.65/105 in 2019; AAPC=0.1 "95% confidence interval (CI): 0.1-0.1"]. In terms of breast cancer mortality attributed to modifiable factors, a 3% increase was observed from 1990 (20.4%) to 2019 (23.1%), the highest contributor being high body mass index (3.19% in 1990 to 5.87% in 2019; AAPC=1.5; 95% CI: 1.3-1.5), followed by high fasting plasma glucose (5.01% in 1990 to 7.72% in 2019; AAPC=1.4; 95% CI: 1.3-1.5).

Conclusion: The proportion of breast cancer-related deaths attributed to metabolic factors has been increasing in Türkiye from 1990 to 2019. Therefore, health policies aimed at managing metabolic factors in women are warranted to reduce breast cancer-related mortality in Türkiye.

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1990 年至 2019 年土耳其乳腺癌死亡率的可改变风险因素:全球疾病负担数据的时间分析。
研究背景目的:探讨1990年至2019年间土耳其女性乳腺癌死亡率的变化趋势以及相关的可改变因素:研究设计:流行病学描述性分析:利用全球疾病负担研究数据库获取 1990 年至 2019 年土耳其女性乳腺癌相关死亡率和可改变(行为和代谢)风险因素的数据。采用联结点回归法计算了女性乳腺癌死亡率的年均百分比变化(AAPC):从 1990 年到 2009 年,土耳其的乳腺癌死亡率呈上升趋势[从 1990 年的 12.26/105 上升到 2019 年的 12.65/105;AAPC=0.1"95% 置信区间 (CI):0.1-0.1"]。在可改变因素导致的乳腺癌死亡率方面,从1990年(20.4%)到2019年(23.1%),观察到了3%的增长,其中贡献最大的是高体重指数(1990年为3.19%,2019年为5.87%;AAPC=1.5;95% CI:1.3-1.5),其次是高空腹血浆葡萄糖(1990年为5.01%,2019年为7.72%;AAPC=1.4;95% CI:1.3-1.5):从 1990 年到 2019 年,土耳其因代谢因素导致的乳腺癌相关死亡比例一直在上升。因此,有必要制定旨在管理妇女代谢因素的卫生政策,以降低土尔其与乳腺癌相关的死亡率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Balkan Medical Journal
Balkan Medical Journal MEDICINE, GENERAL & INTERNAL-
CiteScore
4.10
自引率
6.70%
发文量
76
审稿时长
6-12 weeks
期刊介绍: The Balkan Medical Journal (Balkan Med J) is a peer-reviewed open-access international journal that publishes interesting clinical and experimental research conducted in all fields of medicine, interesting case reports and clinical images, invited reviews, editorials, letters, comments and letters to the Editor including reports on publication and research ethics. The journal is the official scientific publication of the Trakya University Faculty of Medicine, Edirne, Turkey and is printed six times a year, in January, March, May, July, September and November. The language of the journal is English. The journal is based on independent and unbiased double-blinded peer-reviewed principles. Only unpublished papers that are not under review for publication elsewhere can be submitted. Balkan Medical Journal does not accept multiple submission and duplicate submission even though the previous one was published in a different language. The authors are responsible for the scientific content of the material to be published. The Balkan Medical Journal reserves the right to request any research materials on which the paper is based. The Balkan Medical Journal encourages and enables academicians, researchers, specialists and primary care physicians of Balkan countries to publish their valuable research in all branches of medicine. The primary aim of the journal is to publish original articles with high scientific and ethical quality and serve as a good example of medical publications in the Balkans as well as in the World.
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