Cardiovascular and renal oxidative stress-mediated toxicities associated with bisphenol-A exposures are mitigated by Curcuma longa in rats.

IF 1.9 Q3 CHEMISTRY, MEDICINAL Avicenna Journal of Phytomedicine Pub Date : 2024-03-01 DOI:10.22038/AJP.2023.23367

Temitayo Olabisi Ajibade, Oluwaseun Olanrewaju Esan, Israel Mark Osawere, Moses Olusola Adetona, Oluwasanmi Olayinka Aina, Odunayo Ibraheem Azeez, Ayobami Deborah Obisesan, Ademola Adetokunbo Oyagbemi, Olufunke Eunice Ola-Davies, Temidayo Olutayo Omobowale, Adebowale Benard Saba, Adeolu Alex Adedapo, Momoh Audu Yakubu, Oluwafemi Omoniyi Oguntibeju

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Abstract

Objective: Curcuma longa Rhizome (CLR), due to its potent antioxidant phytochemical constituents, was investigated for its effects on bisphenol A (BPA)-induced cardiovascular and renal damage.

Materials and methods: Sixty rats were randomly selected, and grouped as control, BPA (100 mg/ kg), BPA and CLR 100 mg/kg, BPA and CLR 200 mg/kg, CLR 100 mg/kg, and CLR 200 mg/kg for 21 days. Oxidative stress indices, antioxidant status, blood pressure parameters, genotoxicity, and immunohistochemistry were determined.

Results: Rats exposed to the toxic effects of BPA had heightened blood pressure, lowered frequency of micronucleated polychromatic erythrocytes, and decreased activities of antioxidant enzymes compared with rats treated with CLR. Moreover, administration of CLR significantly (p<0.05) lowered malondialdehyde content and reduced the serum myeloperoxidase activity. Immunohistochemical evaluation revealed significantly (p<0.05) increased expressions of cardiac troponin and Caspase 3 in the BPA group compared with the CLR-treated groups.

Conclusion: C. longa ameliorated cardiotoxic and nephrotoxic actions of bisphenol-A via mitigation of oxidative stress, hypertension, and genotoxicity.

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莪术可减轻大鼠因接触双酚 A 而引起的心血管和肾脏氧化应激毒性。

目的：莪术（CLR）具有强效的抗氧化植物化学成分，研究其对双酚 A（BPA）诱导的心血管和肾脏损伤的影响：随机选取 60 只大鼠，按对照组、双酚 A（100 毫克/千克）组、双酚 A 和 CLR 100 毫克/千克组、双酚 A 和 CLR 200 毫克/千克组、CLR 100 毫克/千克组和 CLR 200 毫克/千克组进行分组，连续 21 天。对氧化应激指数、抗氧化状态、血压参数、遗传毒性和免疫组织化学进行了测定：结果：与服用 CLR 的大鼠相比，暴露于双酚 A 毒性效应的大鼠血压升高，微核多染红细胞频率降低，抗氧化酶活性降低。此外，服用 CLR 能显著（p长春花通过减轻氧化应激、高血压和基因毒性，改善了双酚 A 的心脏毒性和肾毒性作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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