Quercetin may reduce the risk of developing the symptoms of COVID-19.

IF 1.9 Q3 CHEMISTRY, MEDICINAL Avicenna Journal of Phytomedicine Pub Date : 2024-03-01 DOI:10.22038/AJP.2023.22920

Marjan Ajami, Mohammadjavad Sotoudeheian, Anahita Houshiar-Rad, Mina Esmaili, Fatemeh Naeini, Fatemeh Mohammadi Nasrabadi, Saied Doaei, Ali Milani-Bonab

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Abstract

Objective: Recent evidence reported that some dietary compounds like quercetin and apigenin as the most well-known flavonoids with anti-inflammatory effects may inhibit SARS-CoV-2 main protease. The hypothesis of the promising effects and possible mechanisms of action of quercetin against COVID-19 were assessed in this article.

Materials and methods: Related papers on the inhibitory effects of quercetin against COVID-19 were collected using the following search strategy: "corona or coronavirus or COVID or COVID-19 or viral or virus" AND "nutrient or flavonoid or Quercetin".

Results: The findings indicated that quercetin can be considered an effective agent against COVID-19 because of its SARS-CoV-2 main protease and RNA-dependent RNA polymerase inhibitory effects. In addition, quercetin may attenuate angiotensin-converting enzyme-2 (ACE-2) receptors leading to a reduction of SARS-CoV-2 ability to enter host cells. Moreover, the antiviral, anti-inflammatory, and immunomodulatory activities of quercetin have been frequently reported.

Conclusion: Quercetin may be an effective agent for managing the complications of COVID-19. Further longitudinal human studies are warranted.

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槲皮素可降低出现 COVID-19 症状的风险。

目的最近有证据表明，一些膳食化合物，如槲皮素和芹菜素，作为最著名的具有抗炎作用的类黄酮，可能会抑制SARS-CoV-2的主要蛋白酶。本文评估了槲皮素对 COVID-19 的预期效果假设和可能的作用机制：采用以下检索策略收集有关槲皮素对 COVID-19 抑制作用的相关论文："冠状病毒或冠状病毒或COVID或COVID-19或病毒或病毒 "和 "营养素或类黄酮或槲皮素"：结果：研究结果表明，槲皮素具有抑制SARS-CoV-2主要蛋白酶和RNA依赖性RNA聚合酶的作用，因此可被视为抗COVID-19的有效药物。此外，槲皮素还能抑制血管紧张素转换酶-2（ACE-2）受体，从而降低 SARS-CoV-2 进入宿主细胞的能力。此外，槲皮素的抗病毒、抗炎和免疫调节活性也屡有报道：结论：槲皮素可能是控制 COVID-19 并发症的有效药物。结论：槲皮素可能是控制 COVID-19 并发症的有效药物，有必要进行进一步的纵向人体研究。

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