Relationship between Vitamin D Concentration and Lipid Concentration in Patients with NAFLD in the Hulunbuir Region of China.

IF 0.7 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY Clinical laboratory Pub Date : 2024-07-01 DOI:10.7754/Clin.Lab.2024.231225

Shihua Zhang, Xiaoyu Jia, Zhanzhu Dong, Xia Li, Xin Li, Hongyan Ge, Chunyu Li

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Abstract

Background: We aimed to characterize the relationship between the serum 25-hydroxyvitamin D concentration and the circulating lipid concentrations of patients with NAFLD in the Hulunbuir region of China.

Methods: One hundred fifty-six patients, who were diagnosed with NAFLD in the Physical Examination Department of the Second Clinical College of Inner Mongolia University for the Nationalities between January 2021 and March 2023, were recruited as NAFLD group, and 160 healthy people were recruited as a control group during the same period. The serum 25(OH)VitD, TBIL, TG, TC, LDL-C, HDL-C, AST, ALT, GGT, and FPG activities of the participants were measured, and hepatic ultrasonography was performed.

Results: The BMI of the NAFLD group was higher than of the control group (p < 0.05). The serum 25(OH)VitD3 (p < 0.05) and the HDL-C concentrations of the NAFLD group were lower than those of the normal control group. However, the AST (p < 0.05), ALT (p < 0.05), and GGT (p < 0.05) activities, and the serum TG (p < 0.05), TC (p < 0.05), LDL-C (p < 0.05), and the fasting glucose (p < 0.05) concentrations of the NAFLD group were higher than those of the normal control group. The serum 25(OH)VitD3 concentrations of the NAFLD group significantly cor-related negatively with BMI (r = -0.302, p < 0.01), TG (r = -0.221, p < 0.05), and fasting glucose (r = -0.236, p < 0.05). The BMI, TG, and fasting glucose of vitamin D-deficient participants were higher than of the participants with adequate or insufficient levels of vitamin D (p < 0.05). Finally, the BMI of vitamin D-deficient participants was higher than of those with an adequate vitamin D status (p < 0.05).

Conclusions: A deficiency of 25(OH)VitD is more common in people from the Hulunbuir region of China than elsewhere. In addition, the vitamin D status is significantly associated with NAFLD; as the serum vitamin D concentration decreases, patients with NAFLD show greater dyslipidemia and hyperglycemia and a higher BMI.

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中国呼伦贝尔地区非酒精性脂肪肝患者维生素 D 浓度与血脂浓度的关系

背景：我们旨在研究中国呼伦贝尔地区非酒精性脂肪肝患者血清25-羟基维生素D浓度与循环血脂浓度之间的关系：目的：探讨中国呼伦贝尔地区非酒精性脂肪肝患者血清25-羟维生素D浓度与循环血脂浓度之间的关系：方法：招募2021年1月至2023年3月期间在内蒙古民族大学第二临床医学院体检科确诊为非酒精性脂肪肝的156名患者作为非酒精性脂肪肝组，同期招募160名健康人作为对照组。结果显示，非酒精性脂肪肝组的体重指数（BMI）高于对照组，差异有统计学意义（P<0.05）；非酒精性脂肪肝组的体重指数（BMI）高于对照组，差异有统计学意义（P<0.05）；非酒精性脂肪肝组的体重指数（BMI）高于对照组，差异有统计学意义（P<0.05）：非酒精性脂肪肝组的体重指数高于对照组（P < 0.05）。非酒精性脂肪肝组的血清 25（OH）VitD3（P < 0.05）和 HDL-C 浓度低于正常对照组。然而，非酒精性脂肪肝组的 AST (p < 0.05)、ALT (p < 0.05) 和 GGT (p < 0.05) 活性、血清 TG (p < 0.05)、TC (p < 0.05)、LDL-C (p < 0.05) 和空腹血糖 (p < 0.05) 浓度均高于正常对照组。非酒精性脂肪肝组的血清25（OH）VitD3浓度与体重指数（BMI）（r = -0.302，p < 0.01）、总胆固醇（TG）（r = -0.221，p < 0.05）和空腹血糖（r = -0.236，p < 0.05）呈显著负相关。缺乏维生素 D 的参与者的体重指数、总胆固醇和空腹血糖均高于维生素 D 水平充足或不足的参与者（P < 0.05）。最后，维生素 D 缺乏者的体重指数高于维生素 D 充足者（P < 0.05）：结论：与其他地区相比，中国呼伦贝尔地区的人更容易缺乏 25（OH）维生素 D。此外，维生素 D 状态与非酒精性脂肪肝密切相关；随着血清维生素 D 浓度的降低，非酒精性脂肪肝患者会出现更严重的血脂异常、高血糖和更高的体重指数。

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来源期刊

Clinical laboratory 医学-医学实验技术

CiteScore

1.50

自引率

0.00%

发文量

494

审稿时长

3 months

期刊介绍： Clinical Laboratory is an international fully peer-reviewed journal covering all aspects of laboratory medicine and transfusion medicine. In addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies. The journal publishes original articles, review articles, posters, short reports, case studies and letters to the editor dealing with 1) the scientific background, implementation and diagnostic significance of laboratory methods employed in hospitals, blood banks and physicians'' offices and with 2) scientific, administrative and clinical aspects of transfusion medicine and 3) in addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies.