Prevalence and Risk Factors of Ocular Demodex at Ultra-High Altitude and Sea Level: A Cross-Sectional Study of Shigatse and Shanghai.

IF 1.9 4区 医学 Q2 OPHTHALMOLOGY Journal of Ocular Pharmacology and Therapeutics Pub Date : 2024-10-01 Epub Date: 2024-07-04 DOI:10.1089/jop.2024.0038
Chunren Meng, Qingquan Wei, Chufeng Gu, Shuai He, Chunyang Cai, Dongwei Lai, Qinghua Qiu
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Abstract

Purpose: Demodex infestation is a risk factor for several ocular surface diseases. However, the prevalence of ocular Demodex infection in the ultra-high altitude population is not clear. This study aimed to compare the prevalence and factors associated with Demodex in populations residing in ultra-high altitude region and sea level areas. Methods: Consecutive patients who visited Shigatse People's Hospital (> 4,000 m) and Shanghai Tongren Hospital (sea level) for eye complaints between January 2023 and January 2024 were included. Subjects were divided into ultra-high altitude and sea level groups. All subjects underwent eyelash epilation for ocular Demodex identification and counting. Demographic and lifestyle information was also collected. Results: A total of 517 subjects were eligible, including 255 subjects in the ultra-high-altitude group and 262 subjects in the sea level group. In the overall analysis, the prevalence of ocular Demodex infection was significantly different between the ultra-high-altitude and sea level groups (15.7% vs. 33.2%, P < 0.001). Multiple logistic regression showed that age, time spent outdoors, and makeup were associated with ocular Demodex infection in both groups. In addition, in the ultra-high-altitude group, people who wear sun hats outdoors were more likely to be infected with Demodex. Conclusion: The infection rate of ocular Demodex in the residents of ultra-high altitude area was significantly lower than that in the residents of sea level area, which may be related to lower ambient temperature, lower humidity, and higher solar radiation. Additionally, age, time spent outdoors, and makeup may be associated with ocular Demodex infection.

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超高海拔地区和海平面地区眼部麦粒肿的患病率和风险因素:日喀则和上海的横断面研究。
目的:Demodex 感染是多种眼表疾病的危险因素之一。然而,超高海拔地区人群的眼部德莫德氏菌感染率尚不清楚。本研究旨在比较居住在超高海拔地区和海平面地区的人群中德莫德菌的感染率和相关因素。研究方法纳入2023年1月至2024年1月期间因眼部不适前往日喀则人民医院(海拔超过4000米)和上海同仁医院(海平面)就诊的连续患者。受试者分为超高海拔组和海平面组。所有受试者都进行了睫毛脱毛,以识别和计算眼部的 Demodex。此外,还收集了人口统计学和生活方式信息。结果共有 517 名受试者符合条件,其中超高海拔组 255 人,海平面组 262 人。在总体分析中,超高海拔组和海平面组的眼部德莫德克感染率有显著差异(15.7% 对 33.2%,P < 0.001)。多元逻辑回归显示,年龄、户外活动时间和化妆与两组的眼部德莫德克感染都有关系。此外,在超高海拔组中,在户外戴遮阳帽的人更容易感染眼部德莫德氏菌。结论超高海拔地区居民的眼部登革热感染率明显低于海平面地区居民,这可能与环境温度较低、湿度较低和太阳辐射较强有关。此外,年龄、户外活动时间和化妆也可能与眼部登革热感染有关。
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来源期刊
CiteScore
4.60
自引率
4.30%
发文量
72
审稿时长
1 months
期刊介绍: Journal of Ocular Pharmacology and Therapeutics is the only peer-reviewed journal that combines the fields of ophthalmology and pharmacology to enable optimal treatment and prevention of ocular diseases and disorders. The Journal delivers the latest discoveries in the pharmacokinetics and pharmacodynamics of therapeutics for the treatment of ophthalmic disorders. Journal of Ocular Pharmacology and Therapeutics coverage includes: Glaucoma Cataracts Retinal degeneration Ocular infection, trauma, and toxicology Ocular drug delivery and biotransformation Ocular pharmacotherapy/clinical trials Ocular inflammatory and immune disorders Gene and cell-based therapies Ocular metabolic disorders Ocular ischemia and blood flow Proliferative disorders of the eye Eyes on Drug Discovery - written by Gary D. Novack, PhD, featuring the latest updates on drug and device pipeline developments as well as policy/regulatory changes by the FDA.
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