Expanding Role for Gallium-68 PET Imaging in Oncology

IF 4.6 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Seminars in nuclear medicine Pub Date : 2024-11-01 DOI:10.1053/j.semnuclmed.2024.06.001
Janke Kleynhans , Thomas Ebenhan , Mike Machaba Sathekge
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Abstract

Gallium-68 has gained substantial momentum since 2003 as a versatile radiometal that is extremely useful for application in the development of novel oncology targeting diagnostic radiopharmaceuticals. It is available through both generator produced radioactivity and via cyclotron production methods and can therefore be implemented in either small- or large-scale production facilities. It can also be implemented within different spectrum of infrastructure settings with relative ease. Whilst many of the radiopharmaceuticals are being development and investigated, which is summarized in this manuscript, [68Ga]Ga-SSTR2 and [68Ga]Ga-PSMA has prominence in current clinical guidelines. The novel tracer [68Ga]Ga-FAPi has also gained significant interest in the clinical context. A comparison of the labelling strategies followed to incorporate gallium-68 and fluorine-18 into the same molecular targeting constructs clearly demonstrate that gallium-68 complexation is the most convenient approach. Recently, cold kit based starting products are available to make the small-scale production of gallium-68 radiopharmaceuticals even more efficient when combined with generator produced gallium-68. The regulatory aspects is currently changing to support the implementation of gallium-68 and other diagnostic radiopharmaceuticals, simplifying the translation towards clinical use. Overall, the development of gallium-68 based radiopharmaceuticals is not only rapidly changing the landscape of diagnosis in oncology, but this growth also promotes innovation and progress in new applications of therapeutic radiometals such as lutetium-177 and actinium-225.
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扩大镓-68 PET 成像在肿瘤学中的作用。
自 2003 年以来,镓-68 作为一种用途广泛的放射性金属,在新型肿瘤靶向诊断放射性药物的开发中发挥了巨大作用。镓-68 既可通过放射性发生器产生,也可通过回旋加速器生产方法获得,因此既可用于小型生产设施,也可用于大型生产设施。它还可以在不同范围的基础设施环境中相对容易地实施。虽然许多放射性药物正在开发和研究中,但[68Ga]Ga-SSTR2 和[68Ga]Ga-PSMA 在当前的临床指南中占有重要地位。新型示踪剂[68Ga]Ga-FAPi也在临床上引起了极大的兴趣。将镓-68 和氟-18 标记到相同的分子靶向构建体中的标记策略比较清楚地表明,镓-68 复合物是最方便的方法。最近,基于冷试剂盒的起始产品问世,与生成器生产的镓-68结合使用,可使镓-68放射性药物的小规模生产更加高效。目前,监管方面正在发生变化,以支持镓-68 和其他诊断性放射性药物的应用,简化向临床应用的转化。总之,以镓-68 为基础的放射性药物的发展不仅迅速改变了肿瘤诊断的格局,而且还促进了镥-177 和锕-225 等治疗放射性金属新应用的创新和进步。
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来源期刊
Seminars in nuclear medicine
Seminars in nuclear medicine 医学-核医学
CiteScore
9.80
自引率
6.10%
发文量
86
审稿时长
14 days
期刊介绍: Seminars in Nuclear Medicine is the leading review journal in nuclear medicine. Each issue brings you expert reviews and commentary on a single topic as selected by the Editors. The journal contains extensive coverage of the field of nuclear medicine, including PET, SPECT, and other molecular imaging studies, and related imaging studies. Full-color illustrations are used throughout to highlight important findings. Seminars is included in PubMed/Medline, Thomson/ISI, and other major scientific indexes.
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