β-Cyclodextrin-based nanoassemblies for the treatment of atherosclerosis.

IF 5.6 1区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS Regenerative Biomaterials Pub Date : 2024-06-17 eCollection Date: 2024-01-01 DOI:10.1093/rb/rbae071
Weihong Ji, Yuanxing Zhang, Weichen Shao, Ranjith Kumar Kankala, Aizheng Chen
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Abstract

Atherosclerosis, a chronic and progressive condition characterized by the accumulation of inflammatory cells and lipids within artery walls, remains a leading cause of cardiovascular diseases globally. Despite considerable advancements in drug therapeutic strategies aimed at managing atherosclerosis, more effective treatment options for atherosclerosis are still warranted. In this pursuit, the emergence of β-cyclodextrin (β-CD) as a promising therapeutic agent offers a novel therapeutic approach to drug delivery targeting atherosclerosis. The hydrophobic cavity of β-CD facilitates its role as a carrier, enabling the encapsulation and delivery of various therapeutic compounds to affected sites within the vasculature. Notably, β-CD-based nanoassemblies possess the ability to reduce cholesterol levels, mitigate inflammation, solubilize hydrophobic drugs and deliver drugs to affected tissues, making these nanocomponents promising candidates for atherosclerosis management. This review focuses on three major classes of β-CD-based nanoassemblies, including β-CD derivatives-based, β-CD/polymer conjugates-based and polymer β-CD-based nanoassemblies, highlighting a variety of formulations and assembly methods to improve drug delivery and therapeutic efficacy. These β-CD-based nanoassemblies exhibit a variety of therapeutic mechanisms for atherosclerosis and offer systematic strategies for overcoming barriers to drug delivery. Finally, we discuss the present obstacles and potential opportunities in the development and application of β-CD-based nanoassemblies as novel therapeutics for managing atherosclerosis and addressing cardiovascular diseases.

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用于治疗动脉粥样硬化的基于β-环糊精的纳米组合物。
动脉粥样硬化是一种慢性渐进性疾病,其特征是炎症细胞和脂质在动脉壁内积聚,它仍然是全球心血管疾病的主要病因。尽管旨在控制动脉粥样硬化的药物治疗策略取得了长足进步,但我们仍然需要更有效的动脉粥样硬化治疗方案。在这方面,β-环糊精(β-CD)作为一种有前途的治疗剂的出现,为针对动脉粥样硬化的药物输送提供了一种新的治疗方法。β-CD 的疏水空腔有利于其发挥载体作用,使各种治疗化合物能够被包裹并输送到血管内受影响的部位。值得注意的是,基于 β-CD 的纳米组合物具有降低胆固醇水平、减轻炎症、溶解疏水性药物和将药物输送到受影响组织的能力,使这些纳米组件成为治疗动脉粥样硬化的理想候选材料。本综述重点介绍基于β-CD的三大类纳米组合物,包括基于β-CD衍生物的纳米组合物、基于β-CD/聚合物共轭物的纳米组合物和基于聚合物β-CD的纳米组合物,重点介绍各种配方和组合方法,以改善药物递送和疗效。这些基于 β-CD 的纳米组合物展示了针对动脉粥样硬化的多种治疗机制,并提供了克服药物输送障碍的系统性策略。最后,我们讨论了目前在开发和应用基于 β-CD 的纳米组合物作为新型疗法来控制动脉粥样硬化和治疗心血管疾病方面存在的障碍和潜在机会。
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来源期刊
Regenerative Biomaterials
Regenerative Biomaterials Materials Science-Biomaterials
CiteScore
7.90
自引率
16.40%
发文量
92
审稿时长
10 weeks
期刊介绍: Regenerative Biomaterials is an international, interdisciplinary, peer-reviewed journal publishing the latest advances in biomaterials and regenerative medicine. The journal provides a forum for the publication of original research papers, reviews, clinical case reports, and commentaries on the topics relevant to the development of advanced regenerative biomaterials concerning novel regenerative technologies and therapeutic approaches for the regeneration and repair of damaged tissues and organs. The interactions of biomaterials with cells and tissue, especially with stem cells, will be of particular focus.
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