Impact of a rash management guide in patients receiving apalutamide for high-risk localized prostate cancer in the Apa-RP study.

IF 5.1 2区 医学 Q1 ONCOLOGY Prostate Cancer and Prostatic Diseases Pub Date : 2024-07-05 DOI:10.1038/s41391-024-00858-4
Neal Shore, Jason Hafron, Daniel Saltzstein, Amitabha Bhaumik, Pankaj Aggarwal, Jennifer Phillips, Tracy McGowan
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Abstract

Background/objectives: Based on the SPARTAN and TITAN studies, apalutamide is approved for patients with nonmetastatic castration-resistant and metastatic castration-sensitive prostate cancer. Skin rash was a common adverse reaction across indications. We hypothesized that earlier identification and intervention could improve rash outcomes.

Subjects/methods: A prespecified rash management guide outlining recommended skin care practices was provided to all patients enrolled in Apa-RP (NCT04523207). Rash-related safety data from Apa-RP were compared descriptively with data from SPARTAN and TITAN.

Results: Patients in Apa-RP experienced improved rash-related outcomes vs those in SPARTAN and TITAN.

Conclusions: Increased vigilance and proactive management may reduce the incidence, severity, and duration of rash during apalutamide treatment.

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在 Apa-RP 研究中,皮疹管理指南对接受阿帕鲁胺治疗高危局部前列腺癌患者的影响。
背景/目的:根据SPARTAN和TITAN研究,阿帕鲁胺被批准用于治疗非转移性阉割耐药和转移性阉割敏感前列腺癌患者。皮疹是各适应症中常见的不良反应。我们假设早期识别和干预可以改善皮疹的治疗效果:向所有入组 Apa-RP (NCT04523207) 的患者提供了预设的皮疹管理指南,其中概述了推荐的皮肤护理方法。将 Apa-RP 中与皮疹相关的安全性数据与 SPARTAN 和 TITAN 的数据进行了描述性比较:结果:与 SPARTAN 和 TITAN 相比,Apa-RP 患者的皮疹相关结果有所改善:结论:提高警惕和积极管理可降低阿帕鲁胺治疗期间皮疹的发生率、严重程度和持续时间。
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来源期刊
Prostate Cancer and Prostatic Diseases
Prostate Cancer and Prostatic Diseases 医学-泌尿学与肾脏学
CiteScore
10.00
自引率
6.20%
发文量
142
审稿时长
6-12 weeks
期刊介绍: Prostate Cancer and Prostatic Diseases covers all aspects of prostatic diseases, in particular prostate cancer, the subject of intensive basic and clinical research world-wide. The journal also reports on exciting new developments being made in diagnosis, surgery, radiotherapy, drug discovery and medical management. Prostate Cancer and Prostatic Diseases is of interest to surgeons, oncologists and clinicians treating patients and to those involved in research into diseases of the prostate. The journal covers the three main areas - prostate cancer, male LUTS and prostatitis. Prostate Cancer and Prostatic Diseases publishes original research articles, reviews, topical comment and critical appraisals of scientific meetings and the latest books. The journal also contains a calendar of forthcoming scientific meetings. The Editors and a distinguished Editorial Board ensure that submitted articles receive fast and efficient attention and are refereed to the highest possible scientific standard. A fast track system is available for topical articles of particular significance.
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