Cutibacterium acnes induces acne-like lesions in hairless mice models - A comparative study

IF 1.3 4区 医学 Q4 PHARMACOLOGY & PHARMACY Journal of pharmacological and toxicological methods Pub Date : 2024-07-01 DOI:10.1016/j.vascn.2024.107539
George Ladopoulos , Christina Barda , Konstantina Tsami , Andrea Vitsos , Nikos Asoutis Didaras , Dimitris Mossialos , Helen Skaltsa , Ioannis Sfiniadakis , G.Th. Papaioannou , Michail Ch. Rallis
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Abstract

Acne vulgaris, a chronic inflammatory skin disease with a high prevalence worldwide, necessitates reliable preclinical models for both understanding its pathogenesis and evaluating potential anti-acne therapies. This study aims to establish a robust mouse model using intracutaneous injection of Cutibacterium acnes bacterial suspension. Three hairless mouse strains (SKH-hr1, SKH-hr2 brown, and SKH-hr2 + ApoE) were systematically compared to ascertain the stains most closely resembling acne in humans. Various assessments, including photo documentation, biophysical evaluation, blood analysis, and histopathology, were conducted. Despite all strains exhibiting acne-like lesions, SKH-hr1 mice emerged as the most suitable model, demonstrating the most satisfactory results across multiple criteria. This research underscores the significance of employing hairless mice strains as models in acne studies to enhance and facilitate the development of effective therapeutic interventions.

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痤疮杆菌诱导无毛小鼠模型出现痤疮样皮损--一项比较研究。
寻常痤疮是一种慢性炎症性皮肤病,在全球发病率很高,需要可靠的临床前模型来了解其发病机制和评估潜在的抗痤疮疗法。本研究旨在通过皮内注射痤疮丙酸杆菌悬浮液来建立一个稳健的小鼠模型。对三种无毛小鼠品系(SKH-hr1、SKH-hr2 棕色品系和 SKH-hr2 + ApoE)进行了系统比较,以确定与人类痤疮最相似的染色。研究人员进行了各种评估,包括照片记录、生物物理评估、血液分析和组织病理学。尽管所有品系都表现出痤疮样皮损,但 SKH-hr1 小鼠成为最合适的模型,在多项标准中表现出最令人满意的结果。这项研究强调了在痤疮研究中采用无毛小鼠品系作为模型的重要性,以加强和促进有效治疗干预措施的开发。
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来源期刊
Journal of pharmacological and toxicological methods
Journal of pharmacological and toxicological methods PHARMACOLOGY & PHARMACY-TOXICOLOGY
CiteScore
3.60
自引率
10.50%
发文量
56
审稿时长
26 days
期刊介绍: Journal of Pharmacological and Toxicological Methods publishes original articles on current methods of investigation used in pharmacology and toxicology. Pharmacology and toxicology are defined in the broadest sense, referring to actions of drugs and chemicals on all living systems. With its international editorial board and noted contributors, Journal of Pharmacological and Toxicological Methods is the leading journal devoted exclusively to experimental procedures used by pharmacologists and toxicologists.
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