Müllerian adenosarcoma with sarcomatous overgrowth and heterologous elements: A case report and literature review

Q4 Medicine Revista Espanola de Patologia Pub Date : 2024-07-01 DOI:10.1016/j.patol.2024.03.003

Miguel Ángel Resano Abarzuza , Saúl De Burgos González , Marta Rezola Bajineta , Manuel Moreno Valladares , Yessica Paulina Rodríguez Velandia , Begoña Aguiar Losada , Iraide Bernal Simón , Paloma Cobas Lozano , Irune Ruiz Díaz

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Abstract

Uterine mullerian adenosarcoma (MA) is a rare biphasic tumour that accounts for less than 0.5% of uterine neoplasms. The age range of presentation is wide, with the median age in the 5th decade of life. It usually has a good prognosis; however, it worsens when it presents with sarcomatous overgrowth, heterologous elements or infiltrates the myometrium.

We report the case of a 63-year-old woman presenting with abnormal vaginal bleeding and a sensation of solid material coming out of the cervical canal who was diagnosed with mullerian adenosarcoma with sarcomatous overgrowth (MASO) and presence of heterologous elements after performing a mass biopsy and subsequent hysterectomy.

We reviewed the literature, focusing especially on the differential diagnoses to be evaluated, as well as the differences in prognosis and treatment according to whether or not they present histologic features of poor prognosis.

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伴有肉瘤过度生长和异种成分的缪勒氏腺肉瘤：病例报告和文献综述

子宫穆勒氏腺肉瘤（MA）是一种罕见的双相肿瘤，占子宫肿瘤的比例不到 0.5%。其发病年龄范围很广，中位年龄为 50 岁。我们报告了一例 63 岁女性的病例，她出现异常阴道出血，感觉有固体物质从宫颈管流出，在进行了肿块活检和随后的子宫切除术后，她被确诊为伴有肉瘤过度生长（MASO）和异种成分存在的穆勒氏腺癌。我们回顾了相关文献，尤其侧重于需要评估的鉴别诊断，以及根据是否出现预后不良的组织学特征而在预后和治疗方面的差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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