Mepitel film for the prevention of radiation dermatitis: A comprehensive review of its efficacy, side effects, physics measurements, patient- and clinician-reported outcomes

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2024-05-31 DOI:10.1016/j.apjon.2024.100530

Olivia Kuszaj , Marley Day , Matt Wronski , Kimberly Corbin , Patries Herst , Rosemary Hill , Dirk Rades , Cindy Wong , Irene Karam , Francois Gallant , Shing Fung Lee , Shirley SW. Tse , Edward Chow , Henry Wong

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Abstract

Objective

This review aimed to summarize the benefits, side effects, physics measurements, and patient- and clinician-reported outcomes of Mepitel film (MF) in preventing radiation dermatitis (RD) for cancer patients.

Methods

The online database PubMed was searched from inception to April 15, 2024 with the search terms “Mepitel film” or “Mepitel.” Articles of any study design evaluating MF for the prevention of RD were included. Non-human studies were excluded.

Results

The database search identified 119 articles and 13 of them were included in this review. Across these studies, MF was found to be beneficial in reducing RD and improved patient- and clinician-reported outcomes in breast and head and neck cancers. Side effects of MF included itchiness, acne, allergic reaction, tightness, discomfort, and poor film adherence, but patient dropouts were uncommon. MF did not cause a bolus effect or increased skin dose in physics measurements.

Conclusions

MF is a safe and effective intervention for preventing acute RD. It should be recommended in breast cancer patients where the data is more robust. Further research is needed to evaluate MF's efficacy on patients with different skin tones, its cost-effectiveness, and identifying patients who most benefit from MF relative to other effective interventions.

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用于预防放射性皮炎的 Mepitel 胶片：对其疗效、副作用、物理测量、患者和临床医生报告结果的全面审查

目的本综述旨在总结美皮护胶片（MF）在预防癌症患者放射性皮炎（RD）方面的益处、副作用、物理测量结果以及患者和临床医生报告的结果。方法以 "美皮护胶片 "或 "美皮护 "为检索词，对在线数据库 PubMed 从开始到 2024 年 4 月 15 日进行了检索。纳入了任何研究设计的文章，这些文章评估了 MF 在预防 RD 方面的作用。结果数据库搜索发现了 119 篇文章，其中 13 篇被纳入本综述。在这些研究中发现，乳腺纤维化疗法有利于减少乳腺癌和头颈部癌症的RD，并改善了患者和临床医生报告的结果。乳腺纤维膜治疗的副作用包括瘙痒、痤疮、过敏反应、紧绷感、不适感和对胶片的依从性差，但患者放弃治疗的情况并不常见。在物理学测量中，MF 没有引起栓剂效应或增加皮肤剂量。乳腺纤维结节是预防急性 RD 的一种安全有效的干预措施，应推荐用于数据更为可靠的乳腺癌患者。需要进一步开展研究，以评估 MF 对不同肤色患者的疗效、成本效益，并确定与其他有效干预措施相比，哪些患者最受益于 MF。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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