The association between bilirubin concentrations and inflammatory bowel disease: Insights from a systematic review and meta-analysis

IF 4.4 3区医学 Q1 MEDICINE, GENERAL & INTERNAL European Journal of Clinical Investigation Pub Date : 2024-07-05 DOI:10.1111/eci.14281

Stefano Zoroddu, Biagio Di Lorenzo, Panagiotis Paliogiannis, Arduino A. Mangoni, Ciriaco Carru, Angelo Zinellu

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Abstract

Background

Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), poses a significant challenge to health care systems because of its chronic nature and increasing global prevalence. Effective management of IBD requires accurate diagnostic tools and biomarkers. This systematic review and meta-analysis aimed to evaluate the relationship between bilirubin concentrations and IBD activity and outcomes.

Methods

A comprehensive search of electronic databases identified 11 studies that included 2606 subjects with IBD and 3607 healthy controls.

Results

Bilirubin concentrations were significantly lower in subjects with IBD when compared to controls (SMD = −0.96, 95% CI −1.21 to −0.70; p < .001). Although substantial heterogeneity was observed, sensitivity analysis confirmed the robustness of the results. Publication bias was detected, but subgroup analyses did not significantly alter the results. Meta-regression showed that age was a significant factor influencing the association between bilirubin concentrations and IBD. Subgroup analyses showed a more pronounced reduction in bilirubin concentrations in subjects with CD than those with UC.

Conclusion

This study supports the potential utility of bilirubin as a biomarker in IBD, emphasizing the need for further research to validate its clinical significance.

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胆红素浓度与炎症性肠病之间的关系：系统回顾和荟萃分析的启示。

背景：炎症性肠病（IBD），包括克罗恩病（CD）和溃疡性结肠炎（UC），由于其慢性性质和全球发病率不断上升，给医疗保健系统带来了巨大挑战。有效管理 IBD 需要准确的诊断工具和生物标志物。本系统综述和荟萃分析旨在评估胆红素浓度与 IBD 活动和结果之间的关系：方法：通过对电子数据库的全面搜索，确定了 11 项研究，其中包括 2606 名 IBD 患者和 3607 名健康对照者：结果：与对照组相比，IBD受试者的胆红素浓度明显降低（SMD = -0.96，95% CI -1.21 to -0.70；P 结论：该研究证实了胆红素浓度的潜在作用：本研究支持胆红素作为 IBD 生物标记物的潜在作用，强调了进一步研究验证其临床意义的必要性。

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来源期刊

European Journal of Clinical Investigation 医学-医学：内科

CiteScore

9.50

自引率

3.60%

发文量

192

审稿时长

1 months

期刊介绍： EJCI considers any original contribution from the most sophisticated basic molecular sciences to applied clinical and translational research and evidence-based medicine across a broad range of subspecialties. The EJCI publishes reports of high-quality research that pertain to the genetic, molecular, cellular, or physiological basis of human biology and disease, as well as research that addresses prevalence, diagnosis, course, treatment, and prevention of disease. We are primarily interested in studies directly pertinent to humans, but submission of robust in vitro and animal work is also encouraged. Interdisciplinary work and research using innovative methods and combinations of laboratory, clinical, and epidemiological methodologies and techniques is of great interest to the journal. Several categories of manuscripts (for detailed description see below) are considered: editorials, original articles (also including randomized clinical trials, systematic reviews and meta-analyses), reviews (narrative reviews), opinion articles (including debates, perspectives and commentaries); and letters to the Editor.