Evaluating the efficacy and safety of trebananib in treating ovarian cancer and non-ovarian cancer patients: a meta-analysis and systematic review.

IF 2.9 3区医学 Q2 ONCOLOGY Expert Review of Anticancer Therapy Pub Date : 2024-09-01 Epub Date: 2024-07-08 DOI:10.1080/14737140.2024.2377793

Jialin Zhang, Jingyang Su, Yeyue Zhou, Jinhua Lu

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Abstract

Objectives: Due to its anti-angiogenic properties, trebananib is frequently employed in the treatment of cancer patients, particularly those with ovarian cancer. We conducted a meta-analysis to assess the efficacy and safety profile of trebananib in combination with other drugs for treating both ovarian and non-ovarian cancer patients.

Methods: Our search encompassed PubMed, Medline, Cochrane, and Embase databases, with a focus on evaluating study quality. Data extraction was conducted from randomized controlled trials (RCTs), and RevMan 5.3 facilitated result analysis.

Results: Combining trebananib with other drugs extended progression-free survival (PFS) [HR 0.81, (95%CI: 0.65, 0.99), p = 0.04] and overall survival (OS) [HR 0.88, (95%CI: 0.79, 1.00), p = 0.04] in ovarian cancer patients. Ovarian cancer patients exhibited a higher objective response rate (ORR) with trebananib compared to non-ovarian cancer cohorts. Moreover, the incorporation of trebananib into the standard treatment regimen for malignant tumors did not significantly elevate drug-related adverse events [RR 1.05, (95% CI: 1.00, 1.11), p = 0.05].

Conclusion: Trebananib plus other drugs can improve the PFS, OS and ORR in patients with cancer, especially ovarian cancer. Our recommendation is to use trebananib plus other drugs to treat advanced cancer, and to continuously monitor and manage drug-related adverse events.

Registration: PROSPERO (No. CRD42023466988).

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评估曲班尼治疗卵巢癌和非卵巢癌患者的疗效和安全性：一项荟萃分析和系统综述。

目的：由于具有抗血管生成的特性，特瑞巴尼经常被用于治疗癌症患者，尤其是卵巢癌患者。我们进行了一项荟萃分析，评估了曲巴尼布与其他药物联合治疗卵巢癌和非卵巢癌患者的疗效和安全性：搜索范围包括PubMed、Medline、Cochrane和Embase数据库，重点评估研究质量。从随机对照试验（RCT）中提取数据，并使用RevMan 5.3进行结果分析：结果：曲巴尼布与其他药物联用可延长卵巢癌患者的无进展生存期（PFS）[HR 0.81，（95%CI：0.65，0.99），p = 0.04]和总生存期（OS）[HR 0.88，（95%CI：0.79，1.00），p = 0.04]。与非卵巢癌队列相比，卵巢癌患者使用曲班尼的客观反应率（ORR）更高。此外，将曲巴尼布纳入恶性肿瘤标准治疗方案并不会显著增加药物相关不良事件[RR 1.05, (95% CI: 1.00, 1.11), p = 0.05]：特瑞巴尼联合其他药物可改善癌症患者，尤其是卵巢癌患者的PFS、OS和ORR。我们建议使用特瑞巴尼布联合其他药物治疗晚期癌症，并持续监测和管理与药物相关的不良反应：注册：PROSPERO（编号：CRD42023466988）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Anticancer Therapy 医学-肿瘤学

CiteScore

5.10

自引率

3.00%

发文量

100

审稿时长

4-8 weeks

期刊介绍： Expert Review of Anticancer Therapy (ISSN 1473-7140) provides expert appraisal and commentary on the major trends in cancer care and highlights the performance of new therapeutic and diagnostic approaches. Coverage includes tumor management, novel medicines, anticancer agents and chemotherapy, biological therapy, cancer vaccines, therapeutic indications, biomarkers and diagnostics, and treatment guidelines. All articles are subject to rigorous peer-review, and the journal makes an essential contribution to decision-making in cancer care. Comprehensive coverage in each review is complemented by the unique Expert Review format and includes the following sections: Expert Opinion - a personal view of the data presented in the article, a discussion on the developments that are likely to be important in the future, and the avenues of research likely to become exciting as further studies yield more detailed results Article Highlights – an executive summary of the author’s most critical points.