Biomarkers in the Immuno-oncology Interface of Triple Negative Breast Cancer: A Scoping Review with Perioperative Considerations.

IF 4.7 2区 医学 Q1 ONCOLOGY Current Oncology Reports Pub Date : 2024-10-01 Epub Date: 2024-07-06 DOI:10.1007/s11912-024-01572-z
Laura Smith, John Saganty, Patrice Forget
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Abstract

Purpose of review: Identification of biomarkers for immunotherapy treatment in triple negative breast cancer remains crucial for improving outcomes and optimising regimes, particularly in the perioperative setting. There is a need to conduct a scoping review to provide an overview of current research, explore the wider context, and highlight future research considerations in this field.

Recent findings: The most commonly assessed biomarkers are PD-L1, TILs and CD8 + cells with correlation to outcomes mainly focused on survival. There is a growing interest in evaluating genetic markers. Conclusions are currently limited by knowledge gaps around contextual factors. Important areas of focus for future research include a greater understanding of complex cellular, genetic and metabolic interactions in the perioperative tumour microenvironment, including patient-specific immune profiles. An important challenge remains elucidating the clinical significance of the immunological effects of interventions at each stage of the perioperative period, including the use of anaesthetic agents.

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三阴性乳腺癌免疫肿瘤学界面的生物标记物:围手术期考虑因素范围综述》。
综述的目的:鉴定三阴性乳腺癌免疫疗法治疗的生物标志物对于改善疗效和优化治疗方案仍然至关重要,尤其是在围手术期。有必要进行一次范围界定综述,以概述当前的研究,探索更广泛的背景,并强调该领域未来研究的注意事项:最常评估的生物标志物是 PD-L1、TILs 和 CD8 + 细胞,与预后的相关性主要集中在存活率上。人们对评估遗传标记物的兴趣日益浓厚。目前,由于对背景因素的认识不足,得出的结论还很有限。未来研究的重点领域包括进一步了解围手术期肿瘤微环境中复杂的细胞、基因和代谢相互作用,包括患者特异性免疫特征。阐明围手术期各阶段干预措施(包括使用麻醉剂)对免疫学影响的临床意义仍是一项重要挑战。
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来源期刊
CiteScore
8.50
自引率
0.00%
发文量
187
审稿时长
6-12 weeks
期刊介绍: This journal aims to review the most important, recently published clinical findings in the field of oncology. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care of those affected by cancer. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as cancer prevention, leukemia, melanoma, neuro-oncology, and palliative medicine. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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