[Positron Emission Tomography Imaging-based Analysis of Biological Functions].

Abstract

Positron emission tomography (PET) refers to a noninvasive imaging modality that enables ultrahigh-sensitivity quantitative evaluation of the spatiotemporal dynamics of targeted molecules within living organisms from outside the body. In this review, we explain the principles of PET imaging technology and the basic properties of ultrahigh sensitivity and quantifiability. Furthermore, we have outlined PET imaging-based integrated approaches to elucidate the fundamental neurobiological mechanisms underlying neuropsychiatric activity, as well as the usefulness of PET imaging in pharmacokinetic analysis and theranostics during drug development.