L. A. Ostrovskaya, D. B. Korman, E. I. Nekrasova, A. K. Chigasova, N. V. Bluhterova, V. A. Rikova, M. M. Fomina, Yu. A. Khochenkova, K. A. Abzaeva
{"title":"Antitumor and Cytotoxic Effect of Silver Polyacrylate","authors":"L. A. Ostrovskaya, D. B. Korman, E. I. Nekrasova, A. K. Chigasova, N. V. Bluhterova, V. A. Rikova, M. M. Fomina, Yu. A. Khochenkova, K. A. Abzaeva","doi":"10.1134/s0006350924700106","DOIUrl":null,"url":null,"abstract":"<p>Silver polyacrylate (argacryl) is shown to have antitumor activity in models of solid mouse tumors in vivo and a cytotoxic effect on human tumor cells in vitro. Argacryl enhances the antitumor effect of cisplatin (Lewis lung carcinoma in mice) and does not show cross resistance with cisplatin and doxorubicin (human breast cancer MCF-7). The molecular mechanism of action of argacryl could be associated with the induction of single-strand DNA breaks in the absence of crosslinking in the DNA molecule.</p>","PeriodicalId":493,"journal":{"name":"Biophysics","volume":null,"pages":null},"PeriodicalIF":4.0330,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biophysics","FirstCategoryId":"4","ListUrlMain":"https://doi.org/10.1134/s0006350924700106","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 0
Abstract
Silver polyacrylate (argacryl) is shown to have antitumor activity in models of solid mouse tumors in vivo and a cytotoxic effect on human tumor cells in vitro. Argacryl enhances the antitumor effect of cisplatin (Lewis lung carcinoma in mice) and does not show cross resistance with cisplatin and doxorubicin (human breast cancer MCF-7). The molecular mechanism of action of argacryl could be associated with the induction of single-strand DNA breaks in the absence of crosslinking in the DNA molecule.
聚丙烯酸银（argacryl）在小鼠实体肿瘤模型中具有体内抗肿瘤活性，在体外对人类肿瘤细胞具有细胞毒性作用。Argacryl 可增强顺铂的抗肿瘤作用（小鼠的 Lewis 肺癌），而且与顺铂和多柔比星（人类乳腺癌 MCF-7）不会产生交叉抗药性。argacryl 的分子作用机制可能与在 DNA 分子没有交联的情况下诱导单链 DNA 断裂有关。
BiophysicsBiochemistry, Genetics and Molecular Biology-Biophysics
CiteScore
1.20
自引率
0.00%
发文量
67
期刊介绍：
Biophysics is a multidisciplinary international peer reviewed journal that covers a wide scope of problems related to the main physical mechanisms of processes taking place at different organization levels in biosystems. It includes structure and dynamics of macromolecules, cells and tissues; the influence of environment; energy transformation and transfer; thermodynamics; biological motility; population dynamics and cell differentiation modeling; biomechanics and tissue rheology; nonlinear phenomena, mathematical and cybernetics modeling of complex systems; and computational biology. The journal publishes short communications devoted and review articles.
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